Evidence map›Paper›PMID 40761549›Full record

ReviewBioactive materials2025

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.

Yu Chen, Haifu Sun, Yonggang Li, Xixi Han, Yuqing Yang, Zheng Chen, Xuequan Zhao, Yuchen Qian, Xishui Liu, Feng Zhou and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu ChenDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Haifu SunDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Yonggang LiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Xixi HanDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Yuqing YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Zheng ChenSchool of Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Xuequan ZhaoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Yuchen QianDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Xishui LiuDepartment of Breast Surgery, Changhai Hospital, Naval Medical University, 800 Xiangyin Road, Shanghai, 200433, China.
Feng ZhouDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Jiaxiang BaiDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, China.
Yusen QiaoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities. It offers unparalleled control over heating areas and temperatures, boasts high efficiency, and results in excellent tissue penetration, while remaining independent of biological tissues. With vast potential in biomedical applications ranging from antitumor therapy to thrombus dissolution, MHT harnesses magnetic nanoparticles (MNPs) to convert magnetic energy into thermal energy under an alternating magnetic field (AMF), thereby achieving therapeutic effects. Advanced magnetic nanocomposite platforms based on magnetic nanoparticles can avoid various risks associated with traditional tools, achieving precise, on-demand, or continuous targeted drug delivery and release through multiple approaches. The potential clinical applications of magnetic hyperthermia therapy are being progressively developed. The present article presents an exhaustive review of the research progress in magnetic hyperthermia therapy. Initially, the overall landscape of MHT was outlined, including physical heat generation mechanisms, types of magnetic nanoparticles and conductive nonmagnetic materials, strategies to increase the thermal efficiency of MNPs, and experimental evidence and research progress on "hot-spot" effects. This review has focused on biomedical applications and targeted drug delivery of innovative combination therapy strategies based on MHT. The progress of clinical trials on MNPs-mediated MHT (MNPs-MHT) is summarized below. Furthermore, the limitations, major challenges and prospects in the clinical translation of MHT are discussed. The objective of this work is to provide a panoramic view of biomedical applications and targeted drug delivery of MHT, which can potentially guide researchers and facilitate the successful implementation of advanced MNPs-MHT systems in the future.

Indexed as

Alternating magnetic fieldBiomedical applicationsClinical trialsDrug deliveryMagnetic hyperthermia therapyMagnetic nanoparticles

Identifiers

PMID40761549
PMCPMC12320187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.