Evidence map›Paper›PMID 40761528›Full record

ArticleBioImpacts : BI2025

Apoptotic and anti-metastatic effect of chrysin on CD44

Yongyong Chen, Jing Zhao, Shaohua Wang, Tao Qi, Shaik Althaf Hussain, Bo Wu

Abstract read
In one paragraph

Article in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yongyong ChenDepartment of Gastroenterology, Xi'an Qinhuang Hospital, Xi'an, 710000, China.ORCID https://orcid.org/0009-0002-1927-4741
Jing ZhaoDepartment of Gastroenterology, Xi'an Qinhuang Hospital, Xi'an, 710000, China.ORCID https://orcid.org/0009-0006-1381-3272
Shaohua WangDepartment of Gastroenterology, Xi'an Qinhuang Hospital, Xi'an, 710000, China.ORCID https://orcid.org/0009-0006-2405-2878
Tao QiDepartment of Gastroenterology, Xi'an Qinhuang Hospital, Xi'an, 710000, China.ORCID https://orcid.org/0009-0009-2875-3876
Shaik Althaf HussainDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0009-0001-6389-9146
Bo WuDepartment of Gastrointestinal Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, 250000, China.ORCID https://orcid.org/0009-0000-2824-3782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cancer stem cells (CSCs) are very important for colorectal cancer (CRC) because they help the cancer start, spread, and metastasise. This makes them a key target for making better cancer treatments. This study explores the effects of chrysin on the CSCs in the SW480 cell line to examine its potential impact on key signalling pathways involved in cell survival and proliferation, shedding light on its therapeutic potential in colon cancer. Methods: Chrysin's cytotoxicity was assessed on CD44 Results: In the following of the MTT assay, 75 μM of chrysin was selected for further experiments. The findings indicated that chrysin significantly enhanced apoptosis in CD44 Conclusion: Chrysin effectively induced apoptosis on CD44

Indexed as

Anti-cancerApoptosisCancer stem cellChrysinColorectal cancerROS generation

Identifiers

PMID40761528
PMCPMC12319216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.