Evidence map›Paper›PMID 40761509›Full record

ReviewMaterials today. Bio2025

Engineering DNA nanopores: from structural evolution to sensing and transport.

Fengyu Liu, Tatsuo Arai, Dezhou Guo, Zhuangde Jiang, Libo Zhao, Xiaoming Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fengyu LiuNational Key Laboratory of Autonomous Intelligent Unmanned Systems, Beijing Institute of Technology, Beijing, 100081, China.
Tatsuo AraiNational Key Laboratory of Autonomous Intelligent Unmanned Systems, Beijing Institute of Technology, Beijing, 100081, China.
Dezhou GuoSchool of Mechatronical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
Zhuangde JiangState Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University, Xi'an, 710049, China.
Libo ZhaoState Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University, Xi'an, 710049, China.
Xiaoming LiuNational Key Laboratory of Autonomous Intelligent Unmanned Systems, Beijing Institute of Technology, Beijing, 100081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic nanopores, inspired by natural ion channels and nuclear pore complexes, hold immense potential for elucidating cellular transport mechanisms and enhancing molecular sensing technologies. DNA nanotechnology, particularly DNA origami, stands out as a transformative platform for designing biomimetic nanopores, leveraging its biocompatibility, structural programmability, and mechanical tunability. This review traces the structural evolution of DNA nanopores across three phases: early hybrid designs with solid-state platforms, vertically-inserted nanopores in lipid bilayers, and horizontally-arranged nanopores with advanced functionalities. Unlike prior reviews, we integrate this progression with critical insights into limitations-such as stability, scalability, and noise-while highlighting breakthroughs in single-molecule sensing and controlled transmembrane transport. We conclude by outlining strategies for next-generation DNA nanopores, offering a roadmap for their optimization in synthetic biology and nanomedicine.

Indexed as

DNA origamiMolecular sensingNanoporesTransmembrane transport

Identifiers

PMID40761509
PMCPMC12320668

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.