Evidence map›Paper›PMID 40761396›Full record

ArticleFrontiers in pharmacology2025

Aerosol inhalation of dimeric artesunate phospholipid-conjugated liposomes ameliorates inflammation, fibrosis, and ferroptosis in neonatal mice with hyperoxia-induced lung injury.

Rong Guan, Yu Chen, Qianqian Yu, Bingrui Yu, Shuyu Chen, Siyuan Jia, Huifang Wang, Huaiping Cheng, Zhaofang Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rong Guan *Department of Neonatology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China.
Yu Chen *Department of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Qianqian YuDepartment of Neonatology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China.
Bingrui YuDepartment of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Shuyu ChenDepartment of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Siyuan JiaDepartment of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Huifang WangDepartment of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Huaiping ChengDepartment of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhaofang TianDepartment of Neonatology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD), a chronic lung condition that impacts preterm infants, results in persistent lung damage with limited therapeutic interventions available. Artemisinin, a bioactive compound derived from Artemisia annua, a member of the Asteraceae family, exhibits potent anti-inflammatory and anti-fibrotic characteristics and has been proven to confer protective benefits against acute lung injuries triggered by various factors. However, its potential impact on BPD and the mechanisms involved are not fully understood. This research examines the function and fundamental processes of dimeric artesunate phospholipid-conjugated liposomes (Di-ART-GPC) in BPD. In the

Indexed as

bronchopulmonary dysplasiaferroptosisfibrosishyperoxiainflammationmacrophages

Identifiers

PMID40761396
PMCPMC12319227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.