ArticleJournal of inflammation research2025
Exploring the Potential of Coix Seeds to Mitigate High Humidity-Induced Gut Inflammation via Microbiota and Metabolite Modulation.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Antihypertensive Peptide ENWAAL Derived fromBiomolecules · 2026Article
- Rapid Monitoring of Storage Deterioration in Processed Coix Seeds Using Near-Infrared Spectroscopy Guided by GC-IMS.Foods (Basel, Switzerland) · 2026Article
- Characterization and immunoprotective efficacy of a fumarate reductaseFrontiers in microbiology · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extreme humidity exacerbates gastrointestinal disorders by disrupting gut microbiota homeostasis, compromising the intestinal barrier and triggering immune dysregulation. Coix seed ( Methods: A Coix seed decoction (CD) was administered to rats exposed to 85% relative humidity (8 h/day) for 30 days. Forty rats were randomly divided into four groups: control, high-humidity exposed, Coix seed-treated control and Coix seed-treated high-humidity. The chemical composition of the CD was characterised using ultra-high-performance liquid chromatography-mass spectrometry (LC-MS), and faecal moisture content, body weight and histopathological changes were assessed. Colonic tissues were analysed by haematoxylin-eosin staining and transmission electron microscopy for structural integrity. Gut microbiota were profiled using 16S ribosomal RNA sequencing, followed by bioinformatic analysis of diversity, differential abundance and co-occurrence networks. Untargeted metabolomics was performed using LC-MS to identify metabolic alterations, and the serum inflammatory cytokines (tumour necrosis factor alpha [TNF-α], interleukin [IL]-6, IL-17) were measured by enzyme-linked immunosorbent assay. Results: High humidity disrupts gut homeostasis in rats by inducing intestinal damage, inflammation, dysbiosis and lipid metabolic disorders. Coix seed decoction significantly alleviated these effects, restoring colonic structure, rebalancing the gut microbiota (eg increasing Conclusion: Our findings provide experimental evidence that Coix seed mitigates high humidity-induced gut injury through microbiota remodelling, lipid metabolic regulation and immune modulation.
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