Evidence map›Paper›PMID 40761377›Full record

ReviewInternational journal of inflammation2025

Netrin-1: Dual Roles in Neuroinflammation and Neurodegenerative Disease Dynamics.

Hadiseh Farahani, Ali Ganji, Ghasem Mosayebi, Mohsen Ebrahimi Monfared, Ali Ghazavi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hadiseh FarahaniDepartment of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Ali GanjiDepartment of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Ghasem MosayebiDepartment of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Mohsen Ebrahimi MonfaredDepartment of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Ali GhazaviDepartment of Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.ORCID https://orcid.org/0000-0002-4219-9594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Netrin-1, a central axonal guidance molecule discovered for its role in neuronal development, is also essential in neurodegenerative diseases. Netrin-1 inhibits leukocyte migration and inflammation-related tissue damage outside the central nervous system. Therefore, it can be viewed as a potential biomarker for inflammatory activity in neurodegenerative diseases. Recent studies highlight the dual roles of Netrin-1 in neuroinflammation and neurodegenerative diseases. In the context of neurodegeneration, Netrin-1 demonstrates both protective and harmful effects. This review highlights recent advancements in research regarding the dual roles of Netrin-1 in neuroinflammation and neurodegeneration. We discuss its involvement in protecting the blood-brain barrier (BBB) and regulating immune cell migration and its effects on various neurodegenerative diseases. A greater understanding of the multifunctionality of Netrin-1 could potentially be employed in developing new treatment modalities.

Indexed as

multiple sclerosisNetrin-1neurodegenerative diseasesneuroinflammationParkinson's disease

Identifiers

PMID40761377
PMCPMC12321422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.