ArticleACG case reports journal2025
Empagliflozin-Induced Nondiabetic Ketoacidosis in Advanced Alcoholic Liver Disease.
Article in ACG case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
A 67-year-old man with advanced alcoholic-associated liver disease developed nondiabetic ketoacidosis shortly after starting empagliflozin for congestive heart failure. He presented with high anion-gap metabolic acidosis, elevated beta-hydroxybutyrate levels, and hypoglycemia. The condition resolved promptly after empagliflozin discontinuation and initiation of intravenous fluids, thiamine, and dextrose therapy. This case highlights the risk of early-onset ketoacidosis in patients with cirrhosis and alcohol use treated with sodium-glucose cotransporter-2 inhibitors, emphasizing careful patient selection and vigilant early monitoring of electrolytes and renal function. As the application of sodium-glucose cotransporter-2 inhibitors expands into managing refractory ascites in cirrhotic patients, further studies are required to confirm their safety.
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