ArticleClinical kidney journal2025
Initial change in fractional excretion of total protein after SGLT2 inhibitors predicts renal prognosis in patients with chronic kidney disease.
Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Fractional Excretion of Total Protein and Long-Term Kidney Outcomes in Patients With Biopsy-Proven Diabetic Nephropathy: The N-BDN Study.Diabetes, obesity & metabolism · 2026Observational
- Dynamics and Predictive Values of Urinary Podocyte Biomarkers Following SGLT2 Inhibition in CKD.Life (Basel, Switzerland) · 2026Article
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Authors and funding
15 authors.
Funding
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Abstract
Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) reduce glomerular hyperfiltration, resulting in an initial estimated glomerular filtration rate (eGFR) dip in chronic kidney disease (CKD). The association between the initial eGFR dip after SGLT2i and proteinuria reduction has not been explored. Fractional excretion of total protein (FETP) is an index of protein leakage corrected for GFR and may be useful in addressing this issue. Methods: FETP was calculated as (serum creatinine × urine protein)/(serum protein × urine creatinine) (in %) and the initial FETP dip was defined as 3 months/baseline FETP. The patients were divided into three groups according to the initial FETP dip tertile: FETP acute dipper, moderate dipper and riser. The association between initial FETP dip after SGLT2i and the eGFR slope over the subsequent 2 years was retrospectively investigated. Results: The study involved 238 patients, including 105 with diabetes mellitus. The patients' median age was 57.0 years and eGFR was 43.0 ml/min/1.73 m Conclusions: An FETP acute dip after SGLT2i is associated with a favourable renal prognosis in CKD, indicating that FETP is a useful index for assessing the efficacy of SGLT2i.
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