Evidence map›Paper›PMID 40761291›Full record

ArticleiScience2025

ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment.

Junya Arai, Yoku Hayakawa, Nobumi Suzuki, Hiroto Kinoshita, Masahiro Hata, Ken Kurokawa, Yuki Matsushita, Sohei Abe, Yukiko Oya, Mayo Tsuboi and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Macrophages in oncoviral infections: from immune regulators to therapeutic targets.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. Role of histone modifications in gastric cancer (Review).International journal of oncology · 2026
    Review
  3. ILC2s and their immune checkpoints in the antitumor response.Journal for immunotherapy of cancer · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Junya AraiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hiroto KinoshitaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Masahiro HataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Ken KurokawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yuki MatsushitaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sohei AbeDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yukiko OyaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Mayo TsuboiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Sozaburo IharaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yusuke IwataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Keita MurakamiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Toshiro ShiokawaDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Chihiro ShiomiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Chie UekuraDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Keisuke YamamotoDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hiroaki FujiwaraDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Satoshi KawamuraDepartment of Gastroenterology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan.
Hayato NakagawaDepartment of Gastroenterology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan.
Tsuneo IkenoueDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hiroaki TatenoCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
Tetsuo UshikuDepartment of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Hideaki IjichiDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yoshihiro HirataDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Masato KasugaThe Institute of Medical Science, Asahi Life Foundation, Tokyo, Japan.
Gloria H SuDepartment of Pathology, Columbia University, New York, NY, USA.
Timothy C WangDivision of Digestive and Liver disease, Department of Medicine, Columbia University, New York, NY, USA.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
NCI NIH HHS R35 CA210088
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CancerCell biologyImmunology

Identifiers

PMID40761291
PMCPMC12319253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.