Evidence map›Paper›PMID 40761290›Full record

ReviewClinical and translational radiation oncology2025

Reirradiation with stereotactic radiosurgery for vestibular schwannomas - a systematic review and meta-analysis.

Noel-Adrian Hollosi, Julie Luise Reimers, Antonio Santacroce, Christoph Fürweger, Markus Kufeld, Anna M E Bruynzeel, Joost J C Verhoeff, Alexander Muacevic, Helen A Shih, Felix Ehret

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noel-Adrian HollosiEdwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Julie Luise ReimersUniversity of Lübeck, Lübeck, Germany.
Antonio SantacroceEuropean Radiosurgery Center Munich, Munich, Germany.
Christoph FürwegerEuropean Radiosurgery Center Munich, Munich, Germany.
Markus KufeldEuropean Radiosurgery Center Munich, Munich, Germany.
Anna M E BruynzeelDepartment of Radiation Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.
Joost J C VerhoeffDepartment of Radiation Oncology, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, the Netherlands.
Alexander MuacevicEuropean Radiosurgery Center Munich, Munich, Germany.
Helen A ShihDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Felix EhretEuropean Radiosurgery Center Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Stereotactic radiosurgery (SRS) is a widely used treatment modality for vestibular schwannomas due to its non-invasive nature and high tumor control rates. However, some patients experience tumor progression after treatment. In this setting, reirradiation with SRS represents a potential treatment option. This systematic review and meta-analysis evaluates the evidence for reirradiation of vestibular schwannomas with SRS. Methods: This systematic literature review and meta-analysis investigates the efficacy and safety of reirradiation with SRS for vestibular schwannoma and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: A total of 806 studies were screened and 35 included, comprising 394 reirradiated patients. The median time from first treatment to reirradiation was 45 months (range: 12 - 65 months). Reirradiation with SRS, applying a median marginal/prescription dose of 12 Gy, achieved an estimated local control of 95% (95% confidence interval (CI): 92 - 97%, I Conclusion: Reirradiation with SRS appears to be a safe and effective salvage treatment for progressive vestibular schwannomas. Prospective studies are warranted to define the optimal dose, timing, and dose constraints for reirradiation.

Indexed as

Acoustic neuromaRadiosurgeryReirradiationStereotactic radiosurgeryVestibular schwannoma

Identifiers

PMID40761290
PMCPMC12320082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.