ArticleFrontiers in microbiology2025
Exploring the effects of resveratrol and β-hydroxy-β-methylbutyric acid under different protein levels on the ileal health of tibetan sheep.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Metagenomic analysis of fecal and environmental microbiota in rural mixed livestock farming systems in South Africa.Frontiers in cellular and infection microbiology · 2026Article
- From Biocontrol to Synthesis: Innovative Progress ofInternational journal of molecular sciences · 2025Review
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Authors and funding
8 authors.
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Abstract
Introduction: Resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) have been shown to improve growth performance in Tibetan sheep by regulating the gut microbiota. This study explored the effects of RES and HMB supplementation on the microbial composition and metabolite levels in the ileum of Tibetan sheep receiving diets with different protein levels. Methods: In a 2 × 2 factorial arrangement, consisting of dietary protein levels (12% and 14%) and feed additive levels (no addition; and RES 1.50 g/d and HMB 1.25 g/d addition). A total of 120 healthy two-month-old male Tibetan lambs (16.87 ± 0.31) were randomly divided into 4 groups ( Results: The results demonstrated that the activities of digestive enzymes (β-amylase, trypsin, lipase, and cellulase), the levels of antibodies (IgA and IgM), and the contents of short-chain fatty acid (SCFA) (butyric acid) were significantly increased in the H-RES-HMB group ( Discussion: Overall, when the dietary protein content was 14%, digestive enzyme activities, immune responses, and SCFAs levels in the ileum were improved, and the mucosal morphology of the ileum was enhanced. When the 14% protein diet was supplemented with RES and HMB, the concentration of butyric acid was increased. This increase was due to the regulation of the ileum microbiota (Firmicutes and
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