ArticleFrontiers in oncology2025
Preoperative ICG fluorescence marking improves lymph node retrieval and survival in laparoscopic gastrectomy for gastric cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness of intraoperative indocyanine green fluorescence imaging in preventing anastomotic leakage after minimally invasive esophagectomy for esophageal cancer: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Indocyanine green-guided lymphadenectomy and survival of patients with gastric cancer: a systematic review and meta-analysis of time-to-event data.Surgical endoscopy · 2026Review
- Progress in the Design and Clinical Application of Probes for Fluorescence-Guided Laparoscopic Surgery.Chemical & biomedical imaging · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While prior studies have suggested the potential benefits of preoperative indocyanine green (ICG) fluorescence marking in laparoscopic gastrectomy, few have evaluated its long-term oncologic impact in large real-world cohorts. This study aimed to validate the clinical utility of preoperative ICG marking by assessing its effects on lymph node retrieval and 3-year survival outcomes in gastric cancer patients. Methods: We retrospectively analyzed resectable gastric cancer patients who underwent laparoscopic gastrectomy at Nanjing First Hospital between January 2020 and December 2021. Patients were allocated to an ICG or non-ICG group. In the ICG group, 1.25 mg/mL ICG was endoscopically injected around the tumor 12 to 24 hours prior to surgery, with near-infrared imaging guiding tumor resection and lymph node (LN) dissection. Propensity score matching yielded 168 matched pairs. Primary outcomes were LN yield and tumor localization accuracy; secondary outcomes included operation time, blood loss, and 3-year disease-free survival (DFS) and overall survival (OS). Multivariable Cox regression analysis was used to identify independent prognostic factors. Results: The ICG group demonstrated a significantly higher mean LN yield (46.4 ± 8.5 vs. 42.6 ± 11.5, Conclusions: Preoperative ICG fluorescence marking is a safe and effective adjunct in laparoscopic gastrectomy for gastric cancer, enhancing surgical efficiency and long-term outcomes.
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