ArticleAnnals of medicine2025
Global burden of atrial fibrillation/atrial flutter and its attributable risk factors in adolescents and young adults, 1990-2021: insights from the global burden of disease study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Modifiable Risk Factors for Atrial Fibrillation/Flutter in the Association of Southeast Asian Nations: Global Burden of Disease 2021.JACC. Advances · 2026Article
- Factors Associated with Atrial Fibrillation in Heart Failure with Preserved and Mildly Reduced Ejection Fraction: A Real-World Cohort Study.Journal of clinical medicine · 2026Article
- Observational
- Pulsed field ablation vs. medical therapy for atrial fibrillation: a propensity score-matched comparison with the JoFib registry.Frontiers in cardiovascular medicine · 2026Article
- Global burden of tobacco-induced atrial fibrillation/flutter: Trends from 1990 to 2021 and projections to 2045 based on the Global Burden of Disease study.Tobacco induced diseases · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to evaluate the global burden trends of atrial fibrillation/flutter with attributable risk factors among adolescents and young adults from 1990 to 2021, particularly in the context of the increasing prevalence of cardiovascular diseases in younger populations. MATERIALS AND
methodsDisease burden data for atrial fibrillation/atrial flutter were sourced from the 2021 Global Burden of Disease Study. The primary metrics were incidence, disability-adjusted life years, and mortality. Population attributable fractions were used to calculate the percentage contribution of the major underlying risk factors to the disease burden.
resultsFrom 1990 to 2021, the global burden of atrial fibrillation/atrial flutter among the studied population increased by 57.26% in incidence, 71.32% in mortality, and 62.34% in disability-adjusted life years. The rate increases were 15.87%, 26.22%, and 19.61%, respectively. The burden of atrial fibrillation/atrial flutter in 2021 and its temporal trends varied significantly according to sex, sociodemographic index quintiles, and geographic location. In 2021, the burden was the highest in the middle-sociodemographic-index regions. Sex differences were found in all potential risk factors of atrial fibrillation/atrial flutter-related mortality and disability-adjusted life year rates. The top three potential risk factors in men were high systolic blood pressure, tobacco exposure, and high alcohol use, and in women, high systolic blood pressure, high body mass index, and tobacco exposure.
conclusionAn imbalance in disease burden across different regions exists. The rapidly increasing disease burden warrants attention, and prevention and treatment strategies should be adjusted to prevent further increase.
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