Evidence map›Paper›PMID 40761112›Full record

ReviewCurrent drug research reviews2025

Searching Heterocyclic Scaffolds Used to Treat Alzheimer's Disease: A Review.

Mayura A Kale, Mohammed Faisal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current drug research reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mayura A KaleGovernment College of Pharmacy, Masur Road, Saidapur, Karad, 415124, Maharashtra, India.ORCID 0000-0002-7124-6716
Mohammed FaisalGovernment College of Pharmacy, Osmanpura, Aurangabad, 431005, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is a known fact that Alzheimer's disease causes degeneration of the central nervous system, which progresses and causes memory loss as well as loss of cognition. For many years, extensive research has been undertaken to find out newer possibilities to fight this disease at a molecular level along with many long-standing and expensive clinical trials. Many scientific research programs have either been discarded or unsuccessful. However, the research has not stopped and in the process, many heterocyclic scaffolds have been tried to build up novel drug molecules to combat this disease. A literature survey reveals that many heterocycles have been explored and were found to be very useful in treating many neurodegenerative disorders, including Alzheimer's disease, Parkinsonism and a few more. This review explains the journey and highlights the various strategies to develop new anti-Alzheimer drug candidates. It is a concise and rigorous literature excerpt involving research findings on heterocyclic scaffolds for treating this disease.

Indexed as

Alzheimer DiseaseHeterocyclic CompoundsAnimalsHumansHeterocyclic CompoundsacetylcholinesteraseAlzheimer's diseaseamyloid-βbiological screeningbutyrylcholinesteraseheterocyclesmolecular docking.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.