Evidence map›Paper›PMID 40761035›Full record

ArticleAdvanced healthcare materials2025

Robust pH Sensing Using a Graphene Oxide and Covalent Organic Frameworks Composite for Gastro-esophageal Reflux Disease Diagnosis.

Ahmed H M Salem, Jianhui Zhang, Ashley Lam, Haowei Wang, Umber Cheema, Laurence B Lovat, Manish K Tiwari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed H M SalemNanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London, WC1E 7JE, UK.
Jianhui ZhangNanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London, WC1E 7JE, UK.
Ashley LamUCL Centre for 3D Models of Health and Disease, UCL Division of Surgery and Interventional Science, Faculty of Medical Sciences, Charles Bell House, University College London, London, W1W 7TY, UK.
Haowei WangCentre for Precision Healthcare, UCL Division of Medicine, University College London, London, WC1E 6JF, UK.
Umber CheemaUCL Centre for 3D Models of Health and Disease, UCL Division of Surgery and Interventional Science, Faculty of Medical Sciences, Charles Bell House, University College London, London, W1W 7TY, UK.
Laurence B LovatUCL Hawkes Institute, University College London, London, W1W 7TS, UK.
Manish K TiwariNanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London, WC1E 7JE, UK.ORCID 0000-0001-5143-6881

Funding

EPSRC studentship from a CDT EP/S021930/1UCL Hospitals Charitable FoundationUK Research and Innovation EP/X023974/1Wellcome / EPSRC Centre for Interventional and Surgical Sciences 203145Z/16/ZWellcome Trust
6 · The paper itself

Abstract

Gastro-esophageal reflux disease affects 15-20% of the global population and is commonly diagnosed via 24-h ambulatory pH monitoring. However, current diagnostic tools, including catheter-based systems and ingestible capsules, suffer from poor patient compliance and unreliable pH readings due to sensor degradation in acidic environments. To address this challenge, a robust, composite pH sensor is reported in this work by combining graphene oxide (GO) with covalent organic frameworks (COFs) coatings. Through interfacial polymerization and liquid-phase exfoliation, the COF protective layer is covalently formed on GO sheets, preserving GO integrity in acidic conditions while enhancing electrochemical performance benefitting from the intrinsic porosity of COFs. The COFs nanochannels with sulfonic groups enable selective proton transport, resulting in high ion selectivity and sensitivity (≈43 mV pH

Indexed as

Gastroesophageal RefluxHydrogen-Ion ConcentrationMetal-Organic FrameworksBiofoulingElectrochemistryEpithelial CellsEsophagusGraphiteHumansLiquid-Liquid Extractiongraphene oxideGraphiteMetal-Organic Frameworksbiocompatibilitycovalent organic frameworksgastro‐oesophageal reflux diseasegraphene oxidepH Sensing

Identifiers

PMID40761035
PMCPMC12716212

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.