Evidence map›Paper›PMID 40761024›Full record

ArticleAdvanced healthcare materials2025

Magnetic Resonance Imaging-Based Quantification of Endosomal Escape Using Iron Oxide Nanoparticle-Loaded Lipid Nanoparticles.

Somin Lee, Jeongbin Park, Han Na Jung, Shengjun Li, Zhijun Lin, Hyung-Jun Im

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Somin LeeDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 03080, Republic of Korea.ORCID 0009-0003-0157-8699
Jeongbin ParkProgram in Biomedical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-5073-3451
Han Na JungDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
Shengjun LiDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 03080, Republic of Korea.
Zhijun LinDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 03080, Republic of Korea.
Hyung-Jun ImDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 03080, Republic of Korea.ORCID 0000-0002-4368-6685

Funding

BK21FOUR Program 5120200513755Korea Drug Development Fund HN22C0632Korea Evaluation Institute of Industrial Technology (KEIT) 20018522Korea Health Industry Development Institute (KHIDI) RS-2024-00439394Korea Health Industry Development Institute (KHIDI) RS-2024-00512498National Research Foundation (NRF) of Korea NRF-2019M2D2A1A01058210National Research Foundation (NRF) of Korea NRF-2020R1C1C1009000National Research Foundation (NRF) of Korea NRF-2021M2E8A1039564National Research Foundation (NRF) of Korea RS-2025-00514210
6 · The paper itself

Abstract

Lipid nanoparticles (LNPs) are considered promising and advanced nucleic acid-based therapeutic delivery platforms. The therapeutic efficacy of LNP-based drugs depends heavily on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying endosomal escape efficiency using magnetic resonance imaging (MRI) is presented. In this method, ultrasmall iron oxide nanoparticles (IONPs) are synthesized and incorporated into LNPs, generating IONPs-loaded LNPs (IO@LNPs). After cellular internalization of IO@LNPs, the R

Indexed as

EndosomesLipidsMagnetic Iron Oxide NanoparticlesMagnetic Resonance ImagingNanoparticlesAnimalsHumansMiceLipidsdrug deliveryendosomal escapein vivo imagingiron oxide nanoparticleslipid nanoparticlesmagnetic resonance imaging

Identifiers

PMID40761024
PMCPMC12645086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.