ArticleEuropean journal of neurology2025
Imaging and Clinical Prognostic Features in Lobar Versus Deep Intracerebral Hemorrhage in an Unselected Swedish Population.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Sex differences in imaging features including cerebral amyloid angiopathy markers in intracerebral hemorrhage.Frontiers in stroke · 2026Article
- Cognitive impairment as a mediator of treatment discontinuation after intracerebral hemorrhage in acute leukemia.Frontiers in medicine · 2026Article
- Imaging and Clinical Prognostic Features in Lobar Versus Deep Intracerebral Hemorrhage in an Unselected Swedish Population.European journal of neurology · 2025Article
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7 authors.
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Abstract
backgroundHematoma location may influence hematoma volume and risk of expansion, the strongest prognostic predictors in patients with intracerebral hemorrhage (ICH). This study aims to determine differences in imaging and clinical factors affecting survival in patients with lobar vs. deep ICH.
methodPatients with spontaneous supratentorial ICH residing in Skåne county registered in the Swedish Stroke Register 2016-2020 were included. Baseline non-contrast CT scans were evaluated for hematoma location and volume, subarachnoid or intraventricular extension, hydrocephalus, and midline shift. Multivariable Cox- and logistic regression analyses were used to determine imaging and clinical factors associated with increased 90-day mortality rate and functional dependency (mRS 3-5).
resultsOf 1398 patients, 666 (48%) had lobar, and 732 (52%) had deep ICH. Lobar ICH volumes were larger (median 27 vs. 13 mL, p < 0.001) compared to deep ICH. At 90 days, the unadjusted mortality rate (34% vs. 32%; p = 0.33) and functional dependency (mRS 3-5: 60.4% vs. 62.4%; p = 0.52) were non-significant between deep and lobar ICH patients. In multivariable analysis adjusted for confounders, hematoma volume (≥ 80 mL (HR = 5.90; 95% CI: 3.40-10.23), 30-79 mL (HR = 4.24; 95% CI: 2.81-6.42), and 10-29 mL (HR = 2.21; 95% CI: 1.49-3.27)), deep ICH location (HR = 1.78, 95% CI: 1.39-2.29), hydrocephalus (HR = 1.69, 95% CI: 1.21-2.37), pre-stroke dependency (HR = 1.51, 95% CI: 1.18-1.94), antiplatelets at onset (HR = 1.47, 95% CI: 1.14-1.90), and age (HR =1.03, 95% CI: 1.02-1.04) were significantly associated with an increased 90-day mortality rate.
conclusionDespite larger hematoma volumes and older age in lobar ICH patients, lobar hemorrhages were associated with a lower mortality rate compared to deep hemorrhages. Our findings highlight the need to consider lobar and deep ICH separately in therapeutic and prognostic studies.
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