ArticleBrain and behavior2025
Association Between Trajectories of Depressive Symptoms and Cardiovascular Disease in Elderly Chinese Adults: Findings From the China Health and Retirement Longitudinal Study (CHARLS).
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and Predictors of Depressive Symptom Trajectories in Older Adults: A Systematic Review.Brain and behavior · 2026Pooled it
- Joint Trajectories of Physical Activity and Depressive Symptoms and Incident Cardiometabolic Multimorbidity: A Multi-Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Depression trajectory modifies the association between estimated glucose disposal rate and incident stroke: a prospective cohort study.BMC cardiovascular disorders · 2026Article
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Abstract
backgroundAlthough the association between depressive symptoms and cardiovascular disease (CVD) has been widely investigated, most existing studies have relied on single-timepoint assessments of depression. Examining longitudinal trajectories of depressive symptoms may provide deeper insights into the dynamic and complex relationship between depression and CVD risk.
methodsBased on data from the China Health and Retirement Longitudinal Study (CHARLS), this study analyzed the relationship between depressive symptom trajectories and CVD risk through logistic regression modeling and latent category growth modeling (LCGM) and explored causality using two-sample Mendelian randomisation (MR).
resultsThe study found four depressive symptom trajectories among Chinese older adults: low-level symptoms, symptom relief, symptom worsening, and high-level symptoms. Compared with the low-level symptom group, the symptom relief, symptom worsening, and high-level symptom groups had a significantly increased risk of CVD, with ORs of 1.51, 1.60, and 2.87, respectively (all P values < 0.05). MR analyses also showed a significant association between depressive symptoms and CVD risk.
conclusionsThe study indicates that longitudinal assessment of depressive symptom trajectories provides a more robust prediction of CVD risk compared to single-timepoint assessments.
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