Evidence map›Paper›PMID 40760806›Full record

ArticleBrain and behavior2025

Curcumin Promotes the Recovery of Motor Function After Brachial Plexus Avulsion Injury in Rats.

Sijing Li, Bing He, Guijuan Zhou, Lin Wu, Xuanwei Wen, Limin Deng, Shudong Lin, Guozhi Liu, Shuangxi Chen, Zijian Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sijing Li *Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Bing He *Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Guijuan ZhouDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Lin WuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Xuanwei WenDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Limin DengDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shudong LinDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Guozhi LiuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shuangxi ChenDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0001-7711-9171
Zijian XiaoDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0001-5137-9549

Funding

Key Scientific Research Project of the Hunan Provincial Department of Education 22A0314Key Scientific Research Project of the Hunan Provincial Department of Education 24A0304National Key Clinical Specialties Major Scientific Research Z2023067National Natural Science Foundation of China 82301581
6 · The paper itself

Abstract

background and purposeBrachial plexus root avulsion (BPRA) often results in the loss of upper limb motor function. Curcumin (CUR) has been proven to have neuroprotective properties in various neurological disorders due to the effects of anti-oxidative stress and anti-inflammation. Therefore, in this study, we focused on the effect of CUR on the recovery of motor functions in rats after BPRA.

methodsAdult male Sprague-Dawley rats were used to build the BPRA and reimplantation model and randomly divided into two groups: the NS group (treated with saline) and the CUR group (treated with 40 mg/ml CUR), with 10 rats in each group. After conducting the Terzis grooming test (TGT) to assess the recovery of motor function, the anterior horn of the spinal cord was collected for detecting the inflammatory responses using Western blot, the musculocutaneous nerves were collected for detecting the motor neuron survival and myelination using Luxol fast blue (LFB) staining or real-time quantitative PCR (qRT-PCR), and the biceps brachii were collected for detecting muscle atrophy using hematoxylin and eosin (H&E) staining.

resultsCUR can significantly enhance the motor recovery in rats following BPRA, reduce inflammation in the anterior horn of the spinal cord, improve the motor neuronal survival and axonal remyelination in musculocutaneous nerves, alleviate muscle atrophy.

conclusionCUR promotes the recovery of motor function in rats after BPRA by inhibiting inflammation, reducing motor neuron death, promoting axonal remyelination, and reducing muscle atrophy, thus laying a foundation for the treatment of BPRA with CUR.

Indexed as

Brachial PlexusCurcuminNeuroprotective AgentsRecovery of FunctionAnimalsDisease Models, AnimalMaleMotor ActivityMotor NeuronsRadiculopathyRatsRats, Sprague-DawleySpinal CordCurcuminNeuroprotective AgentsBrachial plexus injurycurcumininflammation

Identifiers

PMID40760806
PMCPMC12321955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.