Evidence map›Paper›PMID 40760724›Full record

ArticleGenome biology2025

Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast.

Yueyue Jiang, Yanze Jian, Lingyun Nie, Xin Gu, Ziyi Lu, Yongkang Chu, Xing Liu, Xuebiao Yao, Jin-Qiu Zhou, Shengnan Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yueyue JiangMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Yanze JianMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Lingyun NieMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Xin GuShanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Ziyi LuMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Yongkang ChuMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Xing LiuMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Xuebiao YaoMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
Jin-Qiu ZhouShanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Shengnan ZhengMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. zhengsn@mail.ustc.edu.cn.
Chuanhai FuMOE Key Laboratory for Cellular Dynamics & School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. chuanhai@ustc.edu.cn.

Funding

National Key Research and Development Program of China 2022YFA1303100National Key Research and Development Program of China 2023YFA0913400National Natural Science Foundation of China 32300563National Natural Science Foundation of China 92354304, 32470725 , 31621002the Center for Advanced Interdisciplinary Science and Biomedicine of IHM QYPY20220003the China Postdoctoral Science Foundation 2023TQ0342
6 · The paper itself

Abstract

backgroundGenetic information is stored on multiple chromosomes in eukaryotic organisms and is passed on to offspring through cell division. How chromosome number influences cell division and chromosome segregation is not yet understood.

resultsIn this study, we use artificial chromosome-fusion fission yeast cells, which contain one or two chromosomes, as models to investigate the effects of a reduced chromosome number on mitosis and meiosis. In mitosis, chromosome number reduction, particularly full fusion into one chromosome, prolongs mitotic duration in a manner dependent on the spindle assembly checkpoint and improves chromosome segregation accuracy in spindle assembly checkpoint-deficient cells. By contrast, in meiosis, chromosome number reduction impairs prophase oscillatory nuclear movement, prolongs meiosis I duration but shortens meiosis II duration, and severely compromises meiosis I chromosome segregation.

conclusionsOur work uncovers different effects of reduced chromosome number on mitotic and meiotic stability and offers insights into how organisms may select the appropriate number of chromosomes in evolution.

Indexed as

Chromosomes, FungalMeiosisMitosisSchizosaccharomycesChromosome SegregationSchizosaccharomyces pombe ProteinsSpindle ApparatusSchizosaccharomyces pombe ProteinsChromosome numberFission yeastMeiosisMitosisSpindle assembly checkpoint

Identifiers

PMID40760724
PMCPMC12323286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.