ArticleBMC pediatrics2025
Impact of antenatal corticosteroid therapy on neonatal respiratory outcomes in late preterm births.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Two-stitch versus one-stitch cervical cerclage in women with high risk for preterm birth: a stratified exploratory randomized controlled trial in China.BMC pregnancy and childbirth · 2026Trial
- Clinical Presentation and Management of Acute Exacerbation of Asthma During Pregnancy at a Tertiary Care Hospital.Cureus · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the impact of antenatal corticosteroid therapy (ACT) on neonatal respiratory outcomes in late preterm births, focusing on the interaction between gestational age, mode of delivery, and ACT administration.
methodsA retrospective case-control study was conducted on 452 singleton late preterm pregnancies (34 + 0 to 36 + 6 weeks) between 2014 and 2021. Among these, 197 patients received ACT, while 255 did not. Maternal and neonatal characteristics were collected, and logistic regression analyses were performed to identify predictors of neonatal respiratory complications.
resultsACT was associated with a 42% reduction in the odds of neonatal pulmonary complications (adjusted OR: 0.586; 95% CI: 0.347–0.988; p = 0.045). Gestational age was a significant protective factor, with each additional week reducing the risk of adverse pulmonary outcomes by 60% (adjusted OR: 0.397; 95% CI: 0.281–0.561; p < 0.001). Cesarean delivery was associated with a nearly fourfold increase in pulmonary complications compared to vaginal delivery (adjusted OR: 3.775; 95% CI: 1.859–7.666; p < 0.001). ACT showed the most significant protective effect in earlier gestational weeks and among cesarean deliveries.
conclusionACT was associated with reduced neonatal pulmonary complications in late preterm pregnancies, particularly among subgroups with earlier gestational age or cesarean delivery, as supported by multivariate and interaction analyses. These findings underscore the importance of individualized antenatal and perinatal management strategies to optimize neonatal outcomes.
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