ArticleBMC pediatrics2025
Preoperative inflammatory markers in pediatric appendicitis: associations with disease severity, postoperative recovery, pain, and surgical outcomes.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The value of interleukin-6 in predicting acute appendicitis in children and distinguishing complicated appendicitis: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Impact of peritoneal fluid culture findings on postoperative outcomes in pediatric patients with complicated appendicitis.Pediatric surgery international · 2026Article
- Risk Factors for False-Positive Ultrasound in Pediatric Acute Appendicitis: A Prospective Cohort Study.Indian journal of pediatrics · 2026Article
- Diagnostic Performance of Interleukin-6 (IL-6) and Membrane Glycoprotein Cluster of Differentiation-64 (CD64) for Acute Appendicitis in Girls Presenting with Lower Abdominal Pain.Diagnostics (Basel, Switzerland) · 2026Article
- Association Between Perioperative Inflammatory Trajectories and Postoperative Hirschsprung-Associated Enterocolitis: Insights from Group-Based Trajectory Modeling.Journal of inflammation research · 2026Article
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Authors and funding
5 authors.
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Abstract
objectiveThis study aims to evaluate the associations between preoperative inflammatory markers and both disease severity, postoperative outcomes (recovery, pain, complications) and postoperative outcomes (recovery, pain, complications) among pediatric patients with pathologically confirmed acute appendicitis.
methodsThis retrospective cohort study analyzed 150 pediatric patients with pathologically confirmed acute appendicitis and included 150 healthy controls solely to establish baseline inflammatory marker levels. Preoperative inflammatory markers including white blood cell count (WBC), neutrophils (NEU), procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), along with Alvarado scores were recorded. Postoperative outcomes included time to ambulation, bowel sound recovery, first defecation, hospital stay duration, 12-hour Visual Analog Scale (VAS) pain scores, and complication rates. All further analyses regarding severity and outcomes were conducted within the appendicitis cohort.
resultsThe preoperative levels of WBC, PCT, CRP, TNF-α, and IL-6 in patients with appendicitis were significantly higher than those in the healthy control group (p < 0.001). Among children with appendicitis, preoperative inflammatory indicators showed strong correlations with Alvarado scores (P < 0.001), and moderate to strong correlations with postoperative bowel sound recovery time (r = 0.5677-0.7698) and hospital stay duration (r = 0.4481-0.5727). Moderate correlations were also observed with postoperative ambulation time (r = 0.3286-0.5676), and weak correlations with time to oral intake (r = 0.3172-0.4727) and postoperative defecation time (r = 0.2354-0.4905). VAS pain scores (r = 0.4558-0.6196) and complication rates (r = 0.4408-0.5684) were also positively correlated with inflammatory markers (all P < 0.001).
conclusionElevated preoperative inflammatory markers are associated with increased disease severity and can predict prolonged recovery, higher postoperative pain, and a greater risk of complication among confirmed pediatric appendicitis cases. These findings support their clinical use in risk stratification and personalized perioperative management.
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