ReviewBMC pediatrics2025
Association between maternal migraine and infantile colic: a narrative review.
Review in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lactobacillus acidophilus for infant colic and microbiota modulation: a randomized clinical trial.BMC pediatrics · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfantile colic (IC) is a common and distressing condition characterized by excessive crying and fussiness in otherwise healthy infants, typically resolving by three to four months of age. The etiology of IC remains poorly understood, but shared mechanisms with maternal migraine, such as genetic predisposition, sensory hypersensitivity, and gastrointestinal dysregulation, suggest a potential association. This narrative review aims to explore the relationship between maternal migraine and IC, summarizing current evidence and potential underlying mechanisms.
methodsA comprehensive search was conducted in electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, from 2010 up to August 22, 2024. Studies were included if they investigated the association between maternal migraine and IC, included human participants, and were published in English. Case-control and cross-sectional studies providing original data were narratively analyzed. Data extraction focused on study characteristics, maternal migraine and IC definitions, and key findings.
resultsOut of 792 screened studies, 8 met the inclusion criteria, including 5 case-control and 3 cross-sectional studies. Most studies demonstrated a significant association between maternal migraine and IC, with maternal migraine increasing the likelihood of IC by 2.6 to 5 times. Proposed mechanisms include dysregulation of the trigeminovascular system, sensory hypersensitivity, disrupted sleep-wake cycles, and shared genetic predisposition. Evidence for paternal migraine's role in IC was inconsistent, with most studies reporting no significant association.
conclusionsThe findings suggest a strong and consistent association between maternal migraine and IC, potentially driven by shared genetic, neurological, and environmental factors. IC may represent an early-life manifestation of migraine-related syndromes. However, variability in study designs and methodologies limits the generalizability of these findings. Future longitudinal and mechanistic studies are needed to clarify the pathways linking maternal migraine to IC and to explore potential interventions for at-risk infants.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.