Evidence map›Paper›PMID 40760437›Full record

ArticleJournal of nanobiotechnology2025

Mechanochemically reprogrammed porous tantalum with synergistic antibacterial and osteogenic properties for the treatment of infectious bone defects.

Yan Sun, Yu Zhang, Kai Zhang, Jiangyu Nan, Zixuan Xiong, Wenbin Liu, Yihe Hu, Pengfei Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan Sun *Department of Orthopedics, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Yu Zhang *Department of Orthopedic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Kai Zhang *Department of Orthopedics, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Jiangyu NanDepartment of Orthopedics, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Zixuan XiongDepartment of Orthopedic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Wenbin LiuDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, 410078, China. liuwenbin1995@126.com.
Yihe HuDepartment of Orthopedics, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China. xy_huyh@163.com.
Pengfei LeiDepartment of Orthopedics, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China. leipengfei@zju.edu.cn.

Funding

National Key Research and Development Program of China 2023YFC2412600Zhejiang Province Leading Geese Plan 2024C03079
6 · The paper itself

Abstract

Infection and poor osseointegration following orthopedic implantation remain significant challenges that can lead to complications, including prosthesis loosening, delayed fracture healing, and even implant failure. Porous tantalum is a game changer in the field of bone implants. In this study, we employed magnetron sputtering technology to modify ZnO particles on the surface of tantalum nanotubes (TaNTs) in porous tantalum, which were mechanochemically reprogrammed to enhance their properties. This approach enabled functionalization without altering the surface microstructure, resulting in the development of a ZnO-modified tantalum nanotube array coating (TaNTs@ZnO) designed to address infection. ZnO coating, applied via magnetron sputtering, exhibits pH-responsive Zn

Indexed as

Anti-Bacterial AgentsOsteogenesisTantalumAnimalsCell DifferentiationCoated Materials, BiocompatibleEscherichia coliMesenchymal Stem CellsMiceNanotubesOsseointegrationPorosityStaphylococcus aureusZinc OxideAnti-Bacterial AgentsCoated Materials, BiocompatibleTantalumZinc OxideAntibacterial propertiesInfectious bone defectsMagnetron sputteringMechanochemically reprogrammedTantalum nanotubes

Identifiers

PMID40760437
PMCPMC12320291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.