Evidence map›Paper›PMID 40760411›Full record

Trial reportBMC geriatrics2025

A 20-week, randomized controlled trial to determine the efficacy of the Aging Well through Interaction and Scientific Education - Action Plan (AgeWISE-AP) program in older Veterans.

Maureen K O'Connor, Julianne Szemko, Jaye E McLaren, Lauren R Moo, Emily E Metcalf, Andrew Nguyen, Malissa L Kraft, Brandon Frank, David Salat, John J Randolph and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06006962 (Aging Well Through Interactions and Scientific Education - Action Plan), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06006962 naactive not recruitingnot on this map

Aging Well Through Interactions and Scientific Education - Action Plan (AgeWISE-AP)

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2024 to 2027Enrolled134ConditionsCognitive AgingArmsAging Well through Interactions and Scientific Education - Action Plan
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maureen K O'ConnorNeuropsychology Service, Bedford VA Healthcare System, 200 Springs Rd, Bedford, MA, 01730, USA. Maureen.Oconnor@va.gov.
Julianne SzemkoNeuropsychology Service, Bedford VA Healthcare System, 200 Springs Rd, Bedford, MA, 01730, USA.
Jaye E McLarenGeriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, USA.
Lauren R MooGeriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, USA.
Emily E MetcalfGeriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, USA.
Andrew NguyenGeriatric Research Education and Clinical Center, Bedford VA Healthcare System, Bedford, MA, USA.
Malissa L KraftNeuropsychology Service, Bedford VA Healthcare System, 200 Springs Rd, Bedford, MA, 01730, USA.
Brandon FrankDepartment of Neurology, Boston University, Boston, MA, USA.
David SalatDepartment of Neurology, Boston University, Boston, MA, USA.
John J RandolphDepartment of Psychiatry, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Yorghos TripodisSchool of Public Health, Boston University, Boston, MA, USA.

Funding

Rehabilitation Research and Development Service I01RX004828-01RRD VA I01 RX004828
6 · The paper itself

Abstract

backgroundAdvancing age is the number one risk factor for cognitive decline and dementia, making cognitive aging a concern for the nearly half of Veterans who are age 65 and older. There has been a growing appreciation for the value of nonpharmacological lifestyle interventions in dementia risk reduction, including consistently exercising, eating a healthy diet, getting sufficient sleep, socializing, and engaging in cognitively stimulating activities. The 12-week Aging Well through Interaction and Scientific Education program (AgeWISE) provides Veterans with education about brain aging and modifiable lifestyle factors that promote cognitive resilience. A pilot study conducted in 2013 revealed modest improvements in AgeWISE participants’ perceived ability to control brain aging.

methodsThe recently funded AgeWISE-Action Plan (AgeWISE-AP) aims to capitalize on the increased feelings of control over brain aging found in the AgeWISE program through the addition of an action plan (AP) component. The AP involves 8 individualized sessions with a Brain Health Interventionist in addition to AgeWISE group participation. A total of 128 Veterans will be enrolled in the study and each will be randomized to one of the two study arms: AgeWISE-AP (intervention arm) or a no treatment control condition. Outcome measures will be administered at baseline (pre-intervention), immediately post-intervention, and 3- and 6-months post-intervention. These outcome measures assess engagement in brain-healthy lifestyle factors, psychological well-being, and cognition. Linear mixed regression models will be used to test the effect of AgeWISE-AP. An exploratory outcome will focus on structural imaging data acquired from a subset of participants at baseline and one year to investigate potential volumetric changes in brain regions of interest. DISCUSSION: Multi-component interventions that provide brain aging education, improve feelings of control over brain aging, and deliver practical assistance with goal setting and attainment are critically needed to improve cognitive outcomes for older adults. The AgeWISE-AP program aims to increase engagement in protective lifestyle factors, and directly target and improve psychological wellbeing and cognition in older Veterans.

trial registrationThis study was registered with ClinicalTrials.gov (NCT06006962) on August 17, 2023.

Indexed as

AgingHealthy AgingVeteransAgedFemaleHumansMalePilot ProjectsRandomized Controlled Trials as TopicAgingLifestyle factorsOlder adultVeterans

Identifiers

PMID40760411
PMCPMC12323235

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.