ReviewPharmaceutical research2025
Cancer-specific Regulation of Metabolic and Epigenetic Pathways by Dietary Phytochemicals.
Review in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Potential of Dietary Agent Daidzein in Cancer Prevention and Treatment: Opportunities and Challenges.Cancers · 2026Review
- Dietary Phytochemicals in Cancer Therapy-From Mechanistic Insights to Combination Strategies.Nutrients · 2026Article
- Type 2 Diabetes Mellitus as a Multisystem Disease: From Insulin Resistance to Organ Crosstalk-A Narrative Review.Biomedicines · 2026Review
- From Phytochemical Characterization to Energy Metabolism-Driven Molecular Responses: The Anticancer Potential ofNutrients · 2026Article
- Plant-Based Diets and Ovarian Cancer Risk.Nutrients · 2026Article
- EZH2 blockade reverses doxorubicin resistance by inducing metabolic vulnerability and enhancing DNA damage in breast cancer.Frontiers in pharmacology · 2026Article
- Integrated metabolomic, nanoformulation, and network pharmacology approach reveals multifunctional bioactivities of anFrontiers in bioengineering and biotechnology · 2026Article
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: a review of molecular mechanisms, clinical implications, and future perspectives.Cellular & molecular biology letters · 2025Review
- Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundCancer is a complex disease triggered by a combination of genetic mutations, metabolic reprogramming, epigenetic modifications, and environmental factors, and is one of the leading health burdens worldwide. Dietary phytochemical are effective in reducing the incidence of cancer by regulating epigenetic and metabolic pathways and possess great potential in cancer prevention and treatment.
objectivesThis review aims to summarize the relevant metabolic and epigenetic changes in cancer, recent research progress in the mechanism study of dietary phytochemicals by regulating key pathways and provides new insights for further research.
methodsWe searched the relevant literature by searching through common databases, such as PubMed, Medline, ScienceDirect, Google Scholar and Web of Science, and summarized the anticancer effects of potential dietary phytochemicals regulating epigenetic and metabolic pathways in common cancers, such as colorectal cancer, prostate cancer, lung cancer, skin cancer, and breast cancer.
resultsNatural phytochemicals not only regulate key pathways, such as DNA methylation, histone modifications, oxidative stress, inflammation, and metabolic reprogramming, but also demonstrate multi-targeted intervention in tumor therapy by inducing apoptosis, inhibiting cell proliferation, angiogenesis, and metastasis. Additionally, the potential of dietary phytochemicals to reverse metabolic and epigenetic changes makes them promising as adjunctive or alternative therapies.
conclusionPhytochemicals exhibit significant effects in cancer prevention and treatment by targeting metabolic and epigenetic regulatory networks. Future research should further explore their mechanisms, clinical translational value, and synergistic effects with traditional therapies to provide theoretical foundations and practical guidance for developing new cancer intervention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.