ArticleJapanese journal of radiology2025
Pulmonary arterial morphological markers on non-contrast CT predicted acute exacerbations and disease progression in chronic obstructive pulmonary disease: a longitudinal cohort study.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of the effects of long-term oxygen therapy combined with exercise rehabilitation on exercise capacity, cardiopulmonary function, and quality of life in patients with COPD.Frontiers in medicine · 2025Pooled it
- Reply to the Letter to the Editor: Methodological considerations regarding the association between emphysema and pulmonary vascular volume heterogeneity.European radiology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
purposeTo investigate the predictive value of pulmonary artery quantitative CT (qCT) parameters for acute exacerbations of COPD (AECOPD) and explore their longitudinal changes in relation to pulmonary function decline. MATERIALS AND
methodsThis retrospective study included 507 COPD patients from XXX Hospital (2012-2024). Non-contrast CT images were analyzed using the FACT-Digital system to derive qCT parameters: arterial blood volume for vessels ≤ 5 mm
resultsFour qCT parameters (TLV, LAA-950%, TAC, and arterial BV5) were used to build predictive models for AE within 1 year and frequent AE. For AE within 1 year prediction, CT model achieved an AUC of 0.817 (95% CI 0.762-0.872), integration with clinical parameters model improved AUC to 0.839 (95% CI 0.803-0.875). Arterial BV5 < 23.715 ml and TAC < 131 emerged as independent predictors. For frequent AE prediction, CT model showed an AUC of 0.767 (95% CI 0.704-0.830), integration with clinical parameters model improved AUC to 0.867 (95% CI 0.825-0.909). Arterial BV5 < 18 ml and TAC < 135 were identified as independent predictors. Arterial BV5 decline was identified as a marginal independent risk factor for GOLD stage progression (P = 0.051, HR = 2.286, 95% CI 0.995-5.252), FEV1 decline > 30 mL/year (P = 0.008, HR = 2.256, 95% CI 1.237-4.115) and FEV1 decline > 50 mL/year (P = 0.001, HR = 2.943, 95% CI 1.525-5.680).
conclusionsThe study demonstrated that reduced small pulmonary arterial volume (BV5) is an independent risk factor for AECOPD and disease progression. Furthermore, during follow-up, decline in small pulmonary arterial volume independently predicted progression of GOLD stages and accelerated decline in lung function.
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