ArticleAnnals of surgical oncology2025
Textbook Outcome After Major Liver Resection for Primary and Secondary Liver Tumors at Specialized German Hepatobiliary Centers: Analysis of the StuDoQ Liver Registry.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07556835 (Ambispective Cohort Study of Clinical and Oncologic Outcomes in Patients Undergoing Liver and Biliary Resection at San Jacopo Hospital, Pistoia), which is not on this map. Cited by 1 paper.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ambispective Cohort Study of Clinical and Oncologic Outcomes in Patients Undergoing Liver and Biliary Resection at San Jacopo Hospital, Pistoia
Who cites it
1 citing paper in PubMed.
- Implementation of a Robotic Liver Surgery Program in a Large Municipal Hospital: A Propensity Score-Matched Analysis of Clinical, Economic, and Learning Curve Outcomes.Journal of clinical medicine · 2026Article
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22 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTextbook outcome (TO) represents the most desirable outcome of surgical quality and care. This study examined the TO of cholangiocarcinoma (CCC), hepatocellular carcinoma (HCC), and colorectal liver metastasis (CRLM) from the StuDoQ liver registry as well as factors that may affect the TO.
methodsAll major liver resections (≥ 3 segments) for CCC, HCC, and CRLM entered in the multicentric StuDoQ liver registry between 2019 and 2022 were retrospectively analyzed. TO was defined by the absence of intraoperative incidents ≥ grade 2 (Oslo criteria), postoperative bile leakage and posthepatectomy liver failure (B/C, ISGLS criteria), major complications (Dindo-Clavien ≥ 3A), 90-day readmission, and mortality rate as well as tumor-free resection margin. Pre- and intraoperative factors that may influence TO were assessed by multivariable analyses.
resultsIn 30 participating centers, a total of 1082 major liver resections were performed for CCC (n = 396, 36%), HCC (n = 214, 20%), and CRLM (n = 472, 44%). TO was achieved in 470 (43%) cases, most often in CRLM (51%). Major complications and intraoperative incidents ≥ 2 were the most frequent limiting factors to achieve TO. Anemia (odds ratio (OR) 0.63, 95% confidence interval (CI) 0.47-0.85), simultaneous resection procedures to the liver resection (OR 0.56, 95% CI 0.36-0.88), hyperbilirubinemia (OR 0.53, 95% CI 0.34-0.83), and cholangitis (OR 0.51, 95% CI 0.28-0.94) were identified as modifiable risk factors preventing achievement of a TO.
conclusionTO after major liver resection was achieved in less than 50% of cases in certified and high-volume HPB centers. Preoperative risk factors were identified that may allow to improve outcome quality.
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