Evidence map›Paper›PMID 40760283›Full record

ArticleLa Radiologia medica2025

Changes in facet orientation may simultaneously affect the potential risk of annulus tears and zygapophyseal joint osteoarthritis: a clinical review and biomechanical simulation.

Zhipeng Xi, Yimin Xie, Shenglu Sun, Xiong Kang, Jingchi Li

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Article in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Zhipeng XiDepartment of Orthopedics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, People's Republic of China.
Yimin XieDepartment of Orthopedics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, People's Republic of China.
Shenglu SunDepartment of Imaging, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu Province, People's Republic of China.
Xiong KangDepartment of Orthopedics, Traditional Chinese Medicine Hospital of Ili Kazak Autonomous Prefecture, Yining, 835000, Xinjiang Uighur Autonomous Region, People's Republic of China. kangxiong6666@126.com.
Jingchi LiDepartment of Orthopedics, Luzhou Key Laboratory of Orthopedic Disorders, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182, Chunhui Road, Luzhou, 646000, Sichuan Province, People's Republic of China. lijingchi9405@163.com.

Funding

Project of National Clinical Research Base of Traditional Chinese Medicine in Jiangsu Province, China JD2022SZXMS07Scientific Research Project of Jiangsu Provincial Health Commission M2022095the Seventh Batch of National Chinese Medicine Experts' Academic Experience Inheritance Work Project 22QGSC6Yili Prefecture Science and Technology Plan Project TSYC202301A087
6 · The paper itself

Abstract

backgroundThe lumbar motion segment, comprising the intervertebral disc and bilateral articular processes, functions as a cohesive unit for load transmission. Morphological alterations in these components can influence local stress distribution, potentially contributing to the development of degenerative changes. Research indicates that sagittally oriented articular processes may reduce the incidence of severe zygapophyseal joint osteoarthritis (ZJOA) by lowering the load transmission ratio. However, this alignment may also heighten the risk of annular tears by intensifying stress concentration.

methodsA retrospective analysis of clinical data from 111 patients was conducted to test this hypothesis. Facet orientations and ZJOA grades were assessed using MRI and CT imaging, while annular integrity was evaluated with diffusion tensor fibre tractography. Regression analyses identified independent predictors for ZJOA severity and annular tears. Furthermore, lumbo-sacral numerical models with varying facet orientations in the L45 motion segment were developed to compute stress distributions on the annulus and facet cartilage, elucidating the biomechanical mechanisms behind the observed clinical phenomena.

resultsConsistent with existing literature, sagittally oriented articular processes were identified as an independent predictor of severe ZJOA. In contrast, coronally oriented processes were associated with a higher incidence of mild ZJOA and a greater likelihood of annular tears. Numerical simulations demonstrated that coronally oriented articular processes shift load transmission anteriorly, thereby increasing stress on the annulus while reducing stress on the facet cartilage, and vice versa.

conclusionsFacet orientation influences local load transmission. Coronally oriented articular processes may reduce ZJOA severity while increasing the risk of annular tears by redistributing load anteriorly. Conversely, sagittally oriented articular processes likely exert the opposite effect on both ZJOA progression and annular integrity, driven by the same biomechanical principles.

Indexed as

Intervertebral DiscLumbar VertebraeOsteoarthritisZygapophyseal JointAdultAgedBiomechanical PhenomenaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedAnnulus tearsDiffusion tensor fibre tractographyFacet orientationLoad transmission patternZygapophyseal joint osteoarthritis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.