ReviewProgress in orthodontics2025
Indications and limits of clear aligner therapy: an international modified Delphi consensus study.
Review in Progress in orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predicting transversal dental arch expansion outcomes with Invisalign aligners in permanent dentition: a systematic review and meta-analysis.Progress in orthodontics · 2026Pooled it
- Predictability of clear aligners in achieving planned dental arch expansion during mixed dentition: a systematic review and meta-analysis.The Angle orthodontist · 2026Pooled it
- Maxillary anterior retraction with clear aligner: a retrospective comparative cohort study of efficiency between periodontally healthy and stable periodontitis patients.Progress in orthodontics · 2026Article
- Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients.International journal of oral science · 2026Review
- Management of complex orthodontic cases using aligners: A comparative study.Bioinformation · 2026Article
- Changes in transverse dimensions in growing patients treated with AMCOP® and electromyographic assessment with Teethan®.Frontiers in dental medicine · 2026Article
- Clear aligner therapy: a scoping review of treatment prediction, clinical effectiveness, and limitations.Frontiers in dental medicine · 2026Review
- Linear Geometric Analysis of Maxillary Expansion in Mixed Dentition: Rapid Palatal Expander Versus Invisalign First System.Dentistry journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aims of this study were to gather expert agreement about essential aspects of clear aligner therapy (CAT) and to determine what research areas need further investigation. MATERIALS AND
methodsA steering committee performed literature selection and compiled a list of 25 statements. This study used a modified Delphi method involving a panel of 23 international orthodontic experts. Six essential areas of CAT were investigated: treatment efficacy, quality of life, side effects, management of growing patients, treatment with extraction, and treatment of periodontal patients. A panel of experts assessed 25 statements using a 5-point Likert scale throughout 3 rounds of the study. A steering committee adjusted statements that failed to achieve consensus through either revision, splitting, merging, or complete removal.
resultsAfter the third round, 22 statements achieved consensus while 3 statements were rejected. The panel agreed that aligners could be used effectively in some types of malocclusions, such as those with mild or moderate crowding or open bite cases. The experts reached a consensus on the biomechanical limits of clear aligners. However, they agreed on the benefits in terms of improved quality of life during treatment and easier maintenance of oral hygiene maneuvers. Regarding specific patient categories, the panelists supported the use of aligners in periodontal patients with tooth migration requiring tipping movements. They also agreed on the advantages of using a rapid palatal expander over aligners in growing patients.
conclusionsThe panel members reached agreement on most topics. However, they acknowledged limitations in the current literature regarding root resorption and orthodontic relapse with CAT compared to fixed appliances. The absence of agreement on treatment duration, effects on skeletal growth, and the management of periodontally compromised patients highlights significant evidence gaps that warrant further research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.