ArticleScientific reports2025
Effect of repeated sprint exercise on immunological responses in adult and adolescent athletes at different stages of biological maturation: a-quasi-experimental-trial.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The acute effect of sprint interval training on the immune system: a systematic review and meta-regression analysis.Frontiers in medicine · 2025Pooled it
- Trial
- Regulatory mechanisms of high-polyphenol dietary intervention on exercise-induced immunosuppression during high-intensity training periods in adolescent athletes: a systems biology analysis based on immune-metabolic pathways.Nutrition & metabolism · 2026Article
- The effect of repeated sprints on immunological modulation and the role of fat-free mass, biological maturation and dietary inflammatory index in male athletes: a quasi-experimental study with insights for training loads control.Frontiers in sports and active living · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Repeated sprint exercise (RSE), widely used in intermittent sports, induces immune changes critical to address for optimizing training and reducing health risks in youth athletes, especially across biological maturation (BM) stages. We analyzed RSE effects on immune factors in adolescent and adult athletes, considering BM stages. Twenty-nine male intermittent-sport athletes (19 hebiatric: 10 pre-peak height velocity [PHV] [12.1 ± 0.6 years], 9 circum-PHV [13.8 ± 0.7 years]; 10 adults [23.2 ± 2.1 years]) performed RSE (3 × 6 × 35 m sprints, 10-sec rest, 5 min interset). Blood was collected pre-, post-, 2 h, and 24 h post-RSE to assess lactate, leukocyte subsets (neutrophils, monocytes, lymphocytes, T/B cells, NK-cells), and cytokines. According to international guidelines for athletic classification, 72% of the participants in this study were classified as level 2 (regional; ~12-19% of the global population), 17% as level 3 (national; ~0.014% of the global population), and 11% as level 4 (international; ~0.0025% of the global population). RSE elevated leukocytes in all groups, with adults showing higher neutrophils and hebiatric athletes elevated T/B cells (p < 0.05). Pre-PHV exhibited reduced neutrophil/cytokine responses versus circum-PHV/adults (p < 0.05). Circum-PHV displayed post-RSE CD4+/CD8 + rises, while adults had the lowest CD4
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Registered trials
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