ArticleAntimicrobial resistance and infection control2025
Protracted outbreaks of VIM-producing Pseudomonas aeruginosa in a surgical intensive care unit in France, January 2018 to June 2024.
Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Clinically Significant Carbapenemases in Gram-Negative Pathogens: Molecular Diversity and Advances in β-Lactamase Inhibitor Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Integrated Phenotypic, Proteomic (MALDI-TOF MS), and Genomic (WGS) Investigation of a Prolonged Hospital Outbreak ofAntibiotics (Basel, Switzerland) · 2026Article
- Evolution and rise of antimicrobial resistance in key public health bacteria within and across the One Health sectors.Future microbiology · 2026Review
- UnderstandingMicroorganisms · 2026Review
- High-risk lineages shape the resistome and virulome of multidrug-resistantFrontiers in cellular and infection microbiology · 2026Article
- Contrast-Linked Pseudomonas Outbreak in a Cardiac Catheterization Laboratory: Case Series and Quality-Improvement Response.JACC. Case reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPseudomonas aeruginosa is frequently responsible for hospital-acquired infections. It may be isolated in healthcare environment where it can survive. Between January 2018 and June 2024, a growing number of VIM-producing Pseudomonas aeruginosa (PA-VIM) were isolated from patients hospitalized in our surgical intensive care unit (SICU). The aim of this study was to investigate SICU long-term PA-VIM outbreaks involving a persistent environmental reservoir.
methodsInvestigations included an active case finding, a matched case-control study to identify factors associated with PA-VIM acquisition, the identification of environmental reservoirs, a whole-genome sequencing analysis of patient and environmental strains, and the implementation of control measures.
resultsDuring these outbreaks, 32 patients were colonized or identified with at least one PA-VIM positive clinical sample during their SICU stay. Factors significantly associated with the PA-VIM acquisition in the conditional univariate analysis included exposure to antibiotics (e.g., carbapenem) and antifungals, and the use of a nasogastric tube and enteral nutrition. Among 342 environmental samples collected in the SICU (including sink drains, syringes and glasses containing syringes used for enteral nutrition), 67 (19.6%) were found positive for PA-VIM. Core-genome Multi-Locus Sequence Typing analysis identified 2 major clones, each including patients and environmental strains.
conclusionsThese long-lasting outbreaks of PA-VIM were associated to a persistent environmental contamination of sink drains. All the strategies aiming at eradicating PA-VIM reservoirs (disinfection, descaling, or replacement of sink drains) failed or only showed a temporary effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.