Evidence map›Paper›PMID 40759955›Full record

ArticleAIDS research and therapy2025

Brief communication: targeted serum proteomics in postpartum South African women living with and without HIV, correlations with anthropometry and adiposity.

Hlengiwe P Madlala, Junyu Chen, Jennifer Jao, Landon Myer, Amy E Mendham, Carmen Pheiffer, Liam Bell, Lara R Dugas, Julia H Goedecke, Yan V Sun and 1 more

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Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Hlengiwe P MadlalaDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory, Cape Town, 7925, South Africa. hlengiwe.madlala@uct.ac.za.
Junyu ChenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jennifer JaoDivision of Infectious Diseases, Department of Pediatrics & Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Landon MyerDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory, Cape Town, 7925, South Africa.
Amy E MendhamRiverland Academy of Clinical Excellence (RACE), Riverland Mallee Coorong Local Health Network, South Australia Health, Berri, SA, Australia.
Carmen PheifferNon-Communicable Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
Liam BellD-CYPHR Regional Hub, Centre for Proteomic and Genomic Research, University of Cape Town, Cape Town, South Africa.
Lara R DugasDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory, Cape Town, 7925, South Africa.
Julia H GoedeckeDivision of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), FIMS International Collaborating Centre of Sports Medicine, University of Cape Town, Cape Town, South Africa.
Yan V SunDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Angela M BengtsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Funding

Multi-omic Predictors of Renal Function among HIV-infected Individuals of African AncestryR01DK125187 · NIDDK · EMORY UNIVERSITY · PI MARCONI, VINCENT CHARLES, SUN, YAN · 2020 to 2024
$4.1M
Addressing the Dual Burden of HIV and non-communicable diseases in pregnancy in South AfricaR21TW011678 · FIC · BROWN UNIVERSITY · PI BENGTSON, ANGELA, MYER, BENJAMIN LANDON · 2020 to 2021
$329k
Metabolomic predictors of weight gain during pregnancy and the postpartum period in South African women living with HIVK43TW012887 · FIC · UNIVERSITY OF CAPE TOWN · PI MADLALA , HLENGIWE · 2024 to 2024
$113k
Emory Center for AIDS Research P30AI050409NIH HHS K43TW012887NIH HHS R01DK125187NIH HHS R21TW011678Population Studies and Training Center at Brown University P2CHD041020Providence/Boston Center for AIDS Research P30AI042853Thuthuka National Research Foundation 121864
6 · The paper itself

Abstract

Postpartum adiposity is associated with long-term risk of cardiovascular disease (CVD), which may be influenced by HIV infection. We investigated cross-sectional correlations between postpartum adiposity measures, and circulating proteins linked to CVD in women living with and without HIV. Irrespective of HIV status, adiposity was positively correlated with fatty acid binding protein 4, leptin and galectin 9; and negatively correlated with insulin-like growth factor binding protein 2 and V-set immunoglobulin domain containing 2. The link between adiposity and CVD-linked circulating proteins underscores the role of protein markers in understanding the cardiometabolic health of postpartum women living with and without HIV. Clinical trial number: Not applicable.

Indexed as

AdiposityCardiovascular DiseasesHIV InfectionsPostpartum PeriodProteomicsAdultAnthropometryBiomarkersCross-Sectional StudiesFemaleHumansLeptinSouth AfricaYoung AdultBiomarkersLeptinAdiposityHIVPostpartumProteomicsSouth africaWomen

Identifiers

PMID40759955
PMCPMC12320358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.