Evidence map›Paper›PMID 40759890›Full record

ReviewNPJ microgravity2025

Space-driven ROS in cells: a hidden danger to astronaut health and food safety.

Majid Mokhtari, Sigrid S Reinsch, Borja Barbero Barcenilla, Kobra Ziyaei, Richard John Barker

Abstract readReview
In one paragraph

Review in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Transposon sequencing revealsApplied and environmental microbiology · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Majid MokhtariDepartment of Bioinformatics, Kish International Campus, University of Tehran, Kish Island, Iran. Majid.mokhtari65@gmail.com.
Sigrid S ReinschSpace Biosciences Division, NASA Ames Research Center, Moffett Field, Santa Clara, CA, 94035, USA.
Borja Barbero BarcenillaDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, TX, 77843, USA.
Kobra ZiyaeiDepartment of Bioinformatics, Kish International Campus, University of Tehran, Kish Island, Iran.
Richard John BarkerSpace Biosciences Division, NASA Ames Research Center, Moffett Field, Santa Clara, CA, 94035, USA. barkerrj@purdue.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astronaut nutrition faces supply, logistics, and cost challenges, making space farming a solution. While plants adapt to space microgravity may trigger oxidative stress. Research shows space-grown plants achieve Earth-like growth, but ROS accumulation remains a concern. This study examines ROS buildup in cells and its risks for astronauts, emphasizing effects on homeostasis, disease pathways, gut microbiome, and nutrition. This research provides new insights into oxidative stress in space missions.

Identifiers

PMID40759890
PMCPMC12322194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.