Evidence map›Paper›PMID 40759843›Full record

ArticleMaternal and child health journal2025

Maternal Sociodemographic Factors, Adiposity, and Pregnancy Outcomes Among Preterm Deliveries Admitted to the Neonatal Intensive Care Unit.

Mary Clare Lipa, Larske M Soepnel, Emily Flammersfeld, Kaavya Adam, Julia Organ, Candice Choo-Kang, Sachin Amin, Bridget Boyd, Lara Dugas

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Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mary Clare LipaStritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Larske M SoepnelDivision of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Emily FlammersfeldStritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Kaavya AdamChildren's Hospital Los Angeles, Los Angeles, CA, USA.
Julia OrganLoyola University Health System, Maywood, IL, USA.
Candice Choo-KangPublic Health Sciences, Parkinson School of Health Sciences & Public Health, Loyola University Chicago, Maywood, IL, USA.
Sachin AminLoyola University Health System, Maywood, IL, USA.
Bridget BoydLoyola University Health System, Maywood, IL, USA.
Lara DugasDivision of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. Ldugas@luc.edu.

Funding

Loyola University Chicago Stritch School of Medicine Loyola University Chicago Stritch School of Medicine
6 · The paper itself

Abstract

introductionPreterm birth represents about 10% of all births in the United States and is known to be influenced by maternal factors, including pre-pregnancy adiposity, measured using BMI. Pre-pregnancy adiposity is influenced by environmental and sociodemographic factors. This exploratory analysis aimed to explore the complex relationship between pre-pregnancy adiposity, sociodemographic factors, and delivery outcomes among preterm deliveries.

methodsIn this retrospective record review study, participants were mothers of infants born before 34 weeks and 6 days gestational age (GA) and admitted to the NICU at Loyola University Medical Center between 2018 and 2020. Maternal data were extracted using EPIC electronic medical record review. We used Chi-square test/Fisher's exact test for categorical variables and Kruskal-Wallis or Mann-Whitney U tests for continuous variables to test for significance across BMI categories. An exploratory multiple linear regression analysis to test the association between gestational age at delivery, obesity/overweight, socioeconomic status, and ethnicity/race was performed and supplemented with permutation testing. Statistical significance was set at p < 0.05.

resultsAmong the 27 included participants, the median maternal age was 34 years. The prevalence of pre-pregnancy obesity was 42.9%. Women with obesity/overweight tended to have a lower GA at delivery than women with a normal pre-pregnancy BMI (29.5 weeks vs. 31 weeks, p = 0.073). GA at delivery trended positively with higher socioeconomic status (B = 4.2, 95%CI 1.4-7.0, p = 0.007), and inversely with having overweight/obesity (B=-3.6, 95%CI -5.7- -1.6, p = 0.002), and identifying as non-Hispanic Asian or non-Hispanic Black race/ethnicity (B=-6.3, 95%CI -10.3- -2.4, p = 0.005 and B=-0.50, 95%CI -7.8- -2.2, p = 0.002, respectively). DISCUSSION: In addition to adiposity, race, ethnicity, and socioeconomic status may be associated with more severe preterm delivery (lower GA). While this exploratory study is limited by the small sample size, our findings highlight the impact of sociodemographic factors on maternal obesity and severity of pregnancy complications in the context of preterm birth with NICU admission.

Indexed as

AdiposityPregnancy OutcomePremature BirthAdultBody Mass IndexFemaleGestational AgeHumansInfant, NewbornIntensive Care Units, NeonatalObesityPregnancyRetrospective StudiesSociodemographic FactorsSocioeconomic FactorsEthnicityPre-pregnancy BMIPreterm deliveryRaceSocioeconomic status

Identifiers

PMID40759843
PMCPMC12460354

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.