Evidence map›Paper›PMID 40759830›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

First evaluation in multiple sclerosis using PET tracer [

Amal Tiss, Nara M Michaelson, Andrew W Russo, Karla M Ramos-Torres, Yang Sun, Nicole E DaSilva, Jacqueline M Noel, Fang Liu, Kuang Gong, Susie Y Huang and 4 more

Registry-linked trialAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04699747 (Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04699747 phase1recruitingnot on this map

Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

TypeinterventionalSponsorMassachusetts General HospitalRan2021 to 2026Enrolled60ConditionsMultiple SclerosisArmsF-18 3F4AP
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amal Tiss *Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Nara M Michaelson *Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Andrew W RussoDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Karla M Ramos-TorresDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Yang SunDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Nicole E DaSilvaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Jacqueline M NoelDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Fang LiuDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Kuang GongDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Susie Y HuangDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Brian PopkoFeinberg School of Medicine, Department of Neurology, Northwestern University, Chicago, IL, 60611, USA.
Suzanne BakerDepartment of Cellular and Tissue Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Eric C KlawiterDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. eklawiter@mgh.harvard.edu.
Pedro BrugarolasDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. pbrugarolas@mgh.harvard.edu.ORCID 0000-0002-7455-2743

Funding

Deep Learning Technology for Rapid Morphological and Quantitative Imaging of Knee PathologyR01AR079442 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Fang Liu · 2022 to 2026
$2.2M
Rapid Three-dimensional Simultaneous Knee Multi-Relaxation MappingR01AR081344 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Fang Liu · 2022 to 2026
$2.0M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
Deep Learning Reconstruction for Rapid Multi-Component RelaxometryR21EB031185 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI LIU, FANG · 2022 to 2024
$690k
Ultra-Fast High-Resolution Multi-Parametric MRI for Characterizing Cartilage Extracellular MatrixR56AR081017 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LIU, FANG · 2023 to 2023
$643k
Massachusetts General Hospital Executive Committee on Research Physician Scientist Development AwardMassachusetts General Hospital Translational Neuroscience Innovation/Anne B. Young FellowshipNIAMS NIH HHS R01 AR079442NIAMS NIH HHS R01 AR081344NIAMS NIH HHS R56 AR081017NIBIB NIH HHS R21 EB031185NINDS NIH HHS R01 NS114066NINDS NIH HHS R01NS114066University of Chicago Innovation Fund Award from the Polsky Center for Innovation and Entrepreneurship
6 · The paper itself

Abstract

purposeMultiple sclerosis is characterized by demyelination and axonal loss in the central nervous system. While magnetic resonance imaging (MRI) is sensitive to myelin changes, conventional sequences lack specificity and cannot reliably distinguish demyelinated lesions with varying axonal integrity. We evaluated the potential of [

methodsThree people with multiple sclerosis and three healthy controls underwent 2 h dynamic PET scanning with arterial blood sampling after administration of 296 MBq of [

results[

conclusionDespite a small sample size, [

trial registrationNCT04699747, Start date March 25

Indexed as

AminopyridinesMultiple SclerosisPositron-Emission TomographyRadiopharmaceuticalsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRadioactive TracersAminopyridinesRadioactive TracersRadiopharmaceuticals[18F]3F4APDemyelinated axonsMultiple sclerosisMWIPET imagingPotassium channels

Identifiers

PMID40759830
PMCPMC12830403

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.