ArticleMedical oncology (Northwood, London, England)2025
ALDH1A1 promotes colorectal cancer metastasis through activating the notch signaling pathway.
Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells.Molecular biology reports · 2026Article
- Targeting the Notch signaling pathway in digestive system cancers: from bench to bedside.Cancer cell international · 2026Review
- Cancer Stem Cells in Colorectal Cancer: From Molecular Mechanisms to Diagnosis, Prognosis and Therapy Implications.Cancers · 2026Review
- Profiles of FGF2, HGF, Fas/CD95, CASP9, ALDH1A1, and GLUT1 in GEP-NETs: A Comparative Tumor-Margin Study Based on Protein Concentration.International journal of molecular sciences · 2026Article
- Exploratory research on therapeutic agents combined with early diagnostic biomarkers for colorectal cancer.Frontiers in pharmacology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) gene is a member of aldehyde dehydrogenase (ALDH) family, and it is closely associated with cancer metastasis. However, the exact mechanism remains to be clarified. In the present study, we aimed to explore the specific mechanism and role of ALDH1A1 in colorectal cancer (CRC) metastasis. The data obtained from GSE41657 dataset and 24 surgical resected CRC samples was analyzed to explore the expression of ALDH1A1 in CRC and its clinical importance. ALDH1Al expression was increased in CRC tissues and correlated to poor prognosis. ALDH1A1 was highly expressed in CRC cells and ALDH1Al knocking down led to reduced proliferation, migration, and invasion of CRC cells. In terms of the mechanisms, ALDH1Al knockdown or inhibiter caused the significantly reduced gene expression of Notch1, JAG1, and HES1. ALDH1A1 activates Notch signaling pathway to promote CRC growth and development. Our study demonstrated that ALDH1Al could promote CRC cell proliferation, migration, and invasion via activating the Notch signaling pathway. Targeting ALDH1Al might be promising for inhibition of CRC metastasis.
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Registered trials
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