Evidence map›Paper›PMID 40759793›Full record

ArticleEMBO molecular medicine2025

Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy.

Benjamin Hunter, Yunwei Zhang, Dylan Harney, Holly McEwen, Yen Chin Koay, Michael Pan, Cassandra Malecki, Jasmine Khor, Robert D Hume, Giovanni Guglielmi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Benjamin HunterPrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-6100-9760
Yunwei ZhangCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Dylan HarneyCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-1148-5838
Holly McEwenSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0002-8233-1553
Yen Chin KoayPrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-6704-5495
Michael PanSchool of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-8978-7350
Cassandra MaleckiPrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2367-9541
Jasmine KhorSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Robert D HumePrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-3694-9333
Giovanni GuglielmiSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Alicia WalkerSchool of Mathematics and Statistics, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Shashwati DuttaSchool of Mathematics and Statistics, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Vijay RajagopalARC Centre of Excellence for the Mathematical Analysis of Cellular Systems, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-5509-402X
Anthony DonCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-1655-1184
Mark LaranceCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-8579-2267
John F O'Sullivan *Precision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-8016-5128
Jean Y H Yang *Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-5271-2603
Sean Lal *Precision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia. sean.lal@sydney.edu.au.ORCID http://orcid.org/0000-0002-5841-560X

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Federal Government | DHAC | National Health and Medical Research Council (NHMRC) G212785National Heart Foundation of Australia (Heart Foundation) 104853National Heart Foundation of Australia (Heart Foundation) 105595NIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544R.T. Hall Trust (Estate of Late R.T. Hall) 2024161R.T. Hall Trust (Estate of Late R.T. Hall) RQ112
6 · The paper itself

Abstract

Ischaemic cardiomyopathy is the most common cause of heart failure and often coexists with diabetes mellitus, which worsens patient symptom burden and outcomes. Yet, their combined effects are seldom investigated and are poorly understood. To uncover the influencing molecular signature defining ischaemic cardiomyopathy with diabetes, we performed multi-omic analyses of ischaemic and non-ischaemic cardiomyopathy with and without diabetes against healthy age-matched donors. Tissue was sourced from pre-mortem human left ventricular myocardium. Fatty acid transport and oxidation proteins were most downregulated in ischaemic cardiomyopathy with diabetes relative to donors. However, the downregulation of acylcarnitines, perilipin, and ketone body, amino acid, and glucose metabolising proteins indicated lipid metabolism may not be entirely impaired. Oxidative phosphorylation, oxidative stress, myofibrosis, and cardiomyocyte cytoarchitecture also appeared exacerbated principally in ischaemic cardiomyopathy with diabetes. These findings indicate that diabetes confounds the pathological phenotype in heart failure, and the need for a paradigm shift regarding lipid metabolism.

Indexed as

Diabetic CardiomyopathiesHeart VentriclesMyocardial IschemiaMyocardiumAgedFemaleHumansLipid MetabolismMaleMiddle AgedConfocal MicroscopyDiabetesHuman MyocardiumIschaemic CardiomyopathyMulti-omics

Identifiers

PMID40759793
PMCPMC12423312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.