ReviewExperimental & molecular medicine2025
Guardians of silence: transcriptional networks in T cell quiescence.
Review in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- An inherent T cell-activating mRNA delivery carrier for in vivo CAR T generation.Nature materials · 2026Article
- AFF3 maintains metabolic quiescence in naive CD8 T cells and prevents premature immune aging.JCI insight · 2026Article
- The Role of CD4Cells · 2026Review
- Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction.bioRxiv : the preprint server for biology · 2026Article
- The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8Frontiers in immunology · 2026Article
- T cell exhaustion in parasitic infections.Frontiers in immunology · 2026Review
- Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The maintenance of quiescence in T cells plays a pivotal role in averting undesired immune reactions and fostering immune homeostasis. Upon receiving external signals of cognate antigen and costimulatory molecules, T cells escape a quiescent state and rapidly proliferate within an exceedingly short timeframe. Nevertheless, for the majority of their lifespan, T cells remain inactive before stimulation, yet they are highly poised to future activation, implicating the presence of dynamic and intricate regulatory processes in a seemingly dormant state. While numerous extrinsic cues have been identified to induce T cell activation from a quiescence currently, intrinsic mechanisms governing T cell quiescence have received limited attention. Here we provide a comprehensive overview of multiple factors involved in T cell quiescence and their molecular mechanisms mainly in the context of transcriptional and post-transcriptional regulation. Given the intricate interplay between the control of T cell quiescence and a variety of diseases including autoimmunity, exhaustion and even tumor control, a thorough understanding of current insights into T cell quiescence affords us a valuable opportunity to advance our comprehension of T cell biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.