ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Evaluation of risk factors and outcomes of neonates with hypoxic ischemic encephalopathy and acute kidney injury.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Acute kidney injury in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: impact of diagnostic criteria and clinical predictors.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal Acute Kidney Injury-An Australian and New Zealand Perspective.Journal of paediatrics and child health · 2026Review
- Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic-ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- HYPER-HIE Phenotype: Postrewarming Systemic Hypertension Following Hypoxic-Ischemic Encephalopathy-A Case Report and Mechanistic Review.Case reports in pediatrics · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess risk factors for acute kidney injury (AKI) in neonates with hypoxic ischemic encephalopathy (HIE) using KDIGO and Gupta definitions, and evaluate long-term kidney function.
methodsRetrospective study including 72 neonates with HIE and prospective evaluation of long-term kidney health data of 33 survivors.
resultsAKI was detected in 49% using KDIGO and 32% using Gupta's definition. KDIGO-defined AKI correlated with thrombocytopenia, low pH, transfusions need, nephrotoxic drugs, and furosemide use (p < 0.05). The Gupta definition showed additional associations with hypotension, cardiac dysfunction, and death (p < 0.05). In a logistic regression model, both definitions linked AKI to nephrotoxic drug exposure and transfusions. Follow-up assessments revealed elevated blood pressure in 12%, hyperfiltration in 18%, and proteinuria in 6% of survivors.
conclusionsThe Gupta definition may help identify AKI in an additional number of neonates with HIE. Long-term monitoring is essential for the early detection of kidney dysfunction.
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