SynthesisScientific reports2025
Synchronous surgery combined preoperative chemotherapy benefits patients suffering pancreatic ductal adenocarcinoma with liver metastases: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Development and validation of a machine learning model for predicting liver metastasis in pancreatic cancer: a retrospective cohort study.Gland surgery · 2026Article
- Intratumoral microbiome: a key regulator and novel therapeutic target for chemoresistance in pancreatic cancer.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have considered pancreatectomy combined with synchronous metastasectomy as a potential treatment option for patients with metastatic pancreatic ductal adenocarcinoma (PDAC). This study aimed to evaluate the role of surgery in PDAC patients with hepatic metastases and to identify the prognostic factors. PubMed, Embase, and Cochrane Library databases were searched and the hazard ratio (HR) with 95% confidence interval (CI) was extracted from eligible studies. Pooled HR with 95% CI were used to reveal the association between synchronous surgery and overall survival (OS). Thirteen studies with 1107 patients were included. The results (pooled HR 0.496, 95% CI 0.414-0.594, I
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Registered trials
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