Evidence map›Paper›PMID 40759696›Full record

ArticleScientific reports2025

Subcellular and macrostructural immediate responders to airblast traumatic brain injury.

Pratheepa Kumari Rasiah, Jacob Hardenburger, Han Dong, Rachael Hardin, Andrea Locke, J Logan Jenkins, Elisabeth Artis, Charles Caskey, Bryan Millis, E Duco Jansen and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Pratheepa Kumari RasiahDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA. pk.rasiah@vanderbilt.edu.
Jacob HardenburgerDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.
Han DongDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.
Rachael HardinDepartment of Ophthalmology & Visual Science, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, USA.
Andrea LockeDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.
J Logan JenkinsDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.
Elisabeth ArtisDepartment of Ophthalmology & Visual Science, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, USA.
Charles CaskeyDepartment of Radiology, Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, USA.
Bryan MillisDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.
E Duco JansenDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.
Tonia S RexDepartment of Ophthalmology & Visual Science, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, USA.
Anita Mahadevan-JansenDepartment of Biomedical Engineering, Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, USA.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Defense Sciences Office, DARPA HR0011-21-2-0011NICHD NIH HHS P50 HD103537
6 · The paper itself

Abstract

Traumatic Brain Injury (TBI) affects millions of people each year, causing loss of workforce, a significant burden on the healthcare system. Research into the biological effects of TBI has focused on cellular and tissue responses in the order of hours to days after exposure. Unfortunately, treatments that address these secondary processes after TBI have not been effective. Addressing earlier events and identifying first responders is necessary to prevent or limit irreversible damage. Here, we analyze molecular and cellular changes that occur during and immediately after injury in the somatosensory cortex of mice after an airblast TBI using various techniques. Early changes recorded within 5 min of TBI injury show persistent calcium activation, followed by unique phosphorylation patterns activating specific protein binding and calcium-activated pathways. Imaging mass lipidomics and Raman microspectroscopy identified conformational changes of lipid membranes, pointing towards membrane damage as the first response to mechanical pressure. Real-time monitoring of blood vessels shows rapid constriction followed by reduced blood flow within minutes of injury. The present study uncovers the early sequence of events in TBI: ionic calcium imbalance occurs within seconds, activating subcellular phosphorylation patterns, which in turn trigger downstream pathways and a parallel destabilization of membrane phospholipids.

Indexed as

Blast InjuriesBrain Injuries, TraumaticSomatosensory CortexAnimalsCalciumDisease Models, AnimalLipidomicsMaleMiceMice, Inbred C57BLPhosphorylationCalciumGCamp6fInjury biomarkersMembrane lipidsOptical imagingPhosphoproteomicsRaman spectroscopyTraumatic brain injuryVascular changes

Identifiers

PMID40759696
PMCPMC12322299

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.