Evidence map›Paper›PMID 40759693›Full record

ArticleScientific reports2025

Anticancer activity of triterpene glycosides from the sea star Solaster pacificus.

Sergey A Dyshlovoy, Jessica Hauschild, Malte Kriegs, Konstantin Hoffer, Olga Y Burenina, Nadja Strewinsky, Timofey V Malyarenko, Alla A Kicha, Natalia V Ivanchina, Valentin A Stonik and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. AMarine drugs · 2025
    Article
  2. Anticancer Activity of Triterpene Glycosides Cucumarioside AInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sergey A DyshlovoyLaboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation With Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany. s.dyshlovoy@uke.de.
Jessica HauschildLaboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation With Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Malte KriegsDepartment of Radiotherapy and Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Konstantin HofferDepartment of Radiotherapy and Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Olga Y BureninaCenter of Molecular and Cellular Biology, Bolshoy Blvd 30 bld1, Moscow, Russian Federation, 121205.
Nadja StrewinskyLaboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation With Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Timofey V MalyarenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospekt 100-let Vladivostoku 159, Vladivostok, Russian Federation, 690022.
Alla A KichaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospekt 100-let Vladivostoku 159, Vladivostok, Russian Federation, 690022.
Natalia V IvanchinaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospekt 100-let Vladivostoku 159, Vladivostok, Russian Federation, 690022.
Valentin A StonikG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospekt 100-let Vladivostoku 159, Vladivostok, Russian Federation, 690022.
Markus GraefenMartini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Carsten BokemeyerLaboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation With Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Gunhild von AmsbergLaboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation With Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C

Indexed as

Antineoplastic AgentsGlycosidesProstatic NeoplasmsStarfishTriterpenesAnimalsApoptosisCell Line, TumorDrug Resistance, NeoplasmHumansMaleAntineoplastic AgentsGlycosidesTriterpenesDrug resistanceMAPKMarine natural compoundsP-glycoproteinProstate cancerSolaster pacificusTriterpene glycosides

Identifiers

PMID40759693
PMCPMC12322260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.