ArticleScientific reports2025
Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS).
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Microbiology of the Built Environment: Applying Our Knowledge for Healthy Indoor Spaces.Environmental science & technology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms are present in all occupied indoor environments, including homes on Earth and within specialized systems like the International Space Station (ISS). Microbes when exposed to excess moisture, such as from an unexpected ventilation system failure, can undergo growth that is associated with material degradation and negative health effects. However, we do not yet understand how exposure of these microbes to excess moisture alters their function. A de novo metatranscriptomic study was performed using dust collected from the US air filtration system of the ISS and incubated in laboratory chambers on Earth at different equilibrium relative humidity (ERH) levels. Changes in fungal function (gene expression) were significantly associated with moisture (adonis2 p = 0.0001). Secondary metabolism and fungal growth genes were upregulated (FDR-adjusted p ≤ 0.001, log2FC ≥ 2) at elevated ERH compared to 50% ERH. Elevated moisture conditions showed upregulation of aflatoxin and fungal allergen genes such as Asp f 4 (log2FC = 26.4, upregulated at 85% ERH compared to 50%) and Alt a 7 (log2FC = 2.98, upregulated at 100% ERH compared to 50%). Our results demonstrate that understanding microbial functional changes in response to elevated moisture will help develop more robust microbial monitoring standards for spacecraft environments to protect astronaut health and spacecraft integrity in low-Earth orbit and beyond.
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