Evidence map›Paper›PMID 40759643›Full record

ArticleNature communications2025

National evidence on glucose-lowering medication use for diabetes from 62 low- and middle-income countries.

Felix Teufel, Pia Roddewig, Maja E Marcus, Michaela Theilmann, Glennis Andall-Brereton, Krishna Aryal, Sina Azadnajafabad, Pascal Bovet, Maria Dorobantu, Farshad Farzadfar and 20 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Metabolism open · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Felix TeufelHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. felix.teufel@emory.edu.ORCID http://orcid.org/0000-0002-5293-4783
Pia RoddewigDepartment of Economics and Centre for Modern Indian Studies, University of Goettingen, Göttingen, Germany.
Maja E MarcusDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Michaela TheilmannDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Glennis Andall-BreretonCaribbean Public Health Agency, Port of Spain, Trinidad and Tobago.
Krishna AryalBergen Centre for Ethics and Priority Setting and Health, University of Bergen, Bergen, Norway.
Sina AzadnajafabadNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-0105-3801
Pascal BovetMinistry of Health, Victoria, Seychelles.ORCID http://orcid.org/0000-0002-0242-4259
Maria DorobantuUniversity of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Farshad FarzadfarNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Corine HouehanouLaboratory of Epidemiology of Chronic and Neurological Diseases, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin.
Abla SibaiEpidemiology and Population Health Department, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
Andrew C StokesDepartment of Global Health, School of Public Health, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8502-3636
Demetre LabadariosFaculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
Mongal GurungHealth Research and Epidemiology Unit, Ministry of Health, Thimphu, Bhutan.
Jutta JorgensenGlobal Health Section, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Khem KarkiDepartment of Community Medicine and Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Nuno LunetDepartment of Public and Forensic Health Sciences and Medical Education, Faculty of Medicine, University of Porto, Porto, Portugal.
Sahar Saeedi MoghaddamEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Kibachio J MwangiDivision of Non-Communicable Diseases, Ministry of Health, Nairobi, Kenya.
Lela SturuaNon-Communicable Disease Department, National Center for Disease Control and Public Health, Tbilisi, Georgia.
Till BärnighausenHeidelberg Institute of Global Health, Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany.
David FloodDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
Pascal GeldsetzerDepartment of Medicine, Division of Primary Care and Population Health, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8878-5505
Albertino DamascenoFaculty of Medicine, University of Eduardo Mondlane, Maputo, Mozambique.ORCID http://orcid.org/0000-0003-0925-494X
Justine DaviesInstitute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.ORCID http://orcid.org/0000-0001-6834-1838
Sebastian VollmerDepartment of Economics and Centre for Modern Indian Studies, University of Goettingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7863-0462
Mohammed K AliHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7266-2503
Jennifer Manne-Goehler *Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Caroline Bulstra *Heidelberg Institute of Global Health, Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany.

Funding

Preventing Weight Gain and Diabetes in People with HIV in South AfricaK23DK125162 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNE-GOEHLER, JENNIFER · 2020 to 2024
$986k
NIDDK NIH HHS K23 DK125162
6 · The paper itself

Abstract

Given rising diabetes prevalence globally, access to diabetes treatments is gaining urgency. Yet, it remains unknown which glucose-lowering medication types people with diabetes across low- and middle-income countries (LMICs) use. In this cross-sectional analysis, we pooled nationally representative data of 223,283 adults aged ≥25 years in 62 LMICs from 2009 to 2019. We found that 51.9% [95%-CI: 49.6%, 54.2%] of 21,715 individuals with diabetes were undiagnosed. Among individuals with diagnosed diabetes, 18.6% [95%-CI: 14.5%, 23.4%] reported using no glucose-lowering medication, 57.3% [95%-CI: 53.1%, 61.4%] only used oral medication, 19.5% [95%-CI: 17.6%, 21.5%] used oral medication and insulin, and 4.7% [95%-CI: 3.9%, 5.6%] used insulin alone. In low-income countries, fewer individuals with diabetes were diagnosed and treated than in middle-income countries. Yet, among individuals who did get diagnosed, insulin use was two-thirds higher in low-income countries (38.9% [95%-CI: 31.6%, 46.7%]) compared to middle-income countries (23.2%; 95%-CI: 21.0%, 25.5%]). This finding could suggest a need for earlier diagnosis and treatment initiation. Our results can inform national and regional drug procurement efforts across LMICs.

Indexed as

Developing CountriesDiabetes MellitusDiabetes Mellitus, Type 2Hypoglycemic AgentsAdultAgedBlood GlucoseCross-Sectional StudiesFemaleHumansInsulinMaleMiddle AgedBlood GlucoseHypoglycemic AgentsInsulin

Identifiers

PMID40759643
PMCPMC12322005

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.