Evidence map›Paper›PMID 40759629›Full record

ArticleNature communications2025

Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis.

Praveen Weeratunga, Bethany Hunter, Martin Sergeant, Joshua Bull, Colin Clelland, Laura Denney, Chaitanya Vuppusetty, Rachel Burgoyne, Jeongmin Woo, Tian Hu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Praveen WeeratungaMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Bethany HunterNewcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Martin SergeantMRC Centre for Computational Biology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7264-2668
Joshua BullWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1475-2898
Colin ClellandAnatomic Pathology, Weill Cornell Medical College, Doha, Qatar.
Laura DenneyMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Chaitanya VuppusettyMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Rachel BurgoyneNewcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Jeongmin WooMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Tian HuMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Lee BorthwickNewcastle University Biosciences Institute, Newcastle upon Tyne, UK.
James ShawNewcastle University Translational and Clinical Research Institute, University of Newcastle, Newcastle, UK.ORCID http://orcid.org/0000-0002-2893-3211
Agne AntanaviciuteMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Andrew FilbyNewcastle University Biosciences Institute, Newcastle upon Tyne, UK.
Helen ByrneWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1771-5910
Andrew FisherNewcastle University Translational and Clinical Research Institute, University of Newcastle, Newcastle, UK.ORCID http://orcid.org/0000-0003-4822-7223
Ling-Pei HoMRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Ling-pei.ho@imm.ox.ac.uk.ORCID http://orcid.org/0000-0001-8319-301X

Funding

DH | National Institute for Health Research (NIHR) 203311RCUK | MRC | Medical Research Foundation MR/S020918/1
6 · The paper itself

Abstract

Healthy alveolar repair relies on the ability of alveolar stem cells to differentiate into specialized epithelial cells for gas exchange. In chronic fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF), this regenerative process is abnormal but the underlying mechanisms remain unclear. Here, using human lung tissue that represents different stages of disease and a 33-plex single-cell imaging mass cytometry (IMC), we present a high-resolution, temporo-spatial cell atlas of the regenerating alveolar niche. With unbiased mathematical methods which quantify statistically enriched interactions, CD206

Indexed as

Idiopathic Pulmonary FibrosisPulmonary AlveoliRegenerationAlveolar Epithelial CellsEpithelial CellsHumansLungMacrophagesSingle-Cell Analysis

Identifiers

PMID40759629
PMCPMC12322046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.