Evidence map›Paper›PMID 40759595›Full record

ArticleThe world journal of men's health2026

Development and Validation of a Genome-Wide Association Study Based Polygenic Risk Score for Prostate Cancer in an Asian Population.

Jiun-Hung Geng, Chia-Cheng Yu, Chao-Yuan Huang, Victor C Lin, Chia-Yang Li, Ming-Tsang Wu, Szu-Chia Chen, Bo-Ying Bao, Shu-Pin Huang

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In one paragraph

Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiun-Hung GengGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-0610-1278
Chia-Cheng YuDivision of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-2620-1914
Chao-Yuan HuangDepartment of Urology, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-9322-6062
Victor C LinDepartment of Urology, E-Da Hospital, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-4647-9902
Chia-Yang LiGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-5689-9850
Ming-Tsang WuPh.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-7307-7816
Szu-Chia ChenResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-1610-4184
Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung, Taiwan.ORCID https://orcid.org/0000-0001-5510-6513
Shu-Pin HuangGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-2968-6125

Funding

Kaohsiung Medical University Research Center KMUH112-2R59Kaohsiung Medical University Research Center KMUH113-3R52Kaohsiung Medical University Research Center KMU-TC109A01-1Kaohsiung Medical University Research Center NHRIKMU-113-I001Kaohsiung Municipal Siaogang Hospital kmhk-112-23Kaohsiung Municipal Siaogang Hospital S-108-017Kaohsiung Municipal Siaogang Hospital S-111-16Kaohsiung Municipal Siaogang Hospital S-112-01Ministry of Science and Technology MOST 111-2314-B-037-061Ministry of Science and Technology MOST 112-2314-B-037-115-MY2Ministry of Science and Technology NSTC 111-2218-E-037-001Ministry of Science and Technology NSTC 112-2218-E-037-001Ministry of Science and Technology NSTC 112-2314-B-037-127Ministry of Science and Technology NSTC 113-2218-E-037-001Ministry of Science and Technology NSTC 113-2314-B-037-016
6 · The paper itself

Abstract

purposeThis study aimed to estimate genetic susceptibility to prostate cancer (PCa) by constructing a polygenic risk score (PRS) using single nucleotide polymorphisms (SNPs) identified from genome-wide association studies. MATERIALS AND

methodsThe study included 1,015 PCa patients from our institutions and 1,015 age-matched controls from the Taiwan Biobank (TWB). An independent external validation cohort of 188 PCa patients and 188 TWB controls (excluding those from the primary cohort) was assembled. DNA was extracted from blood samples, with approximately 690,000 SNPs genotyped (minor allele frequency ≥0.05) and 15 million additional SNPs imputed using the 1000 Genomes Project. After quality control, 958 PCa patients and 999 controls were included in the analysis. The PRS was developed using PRSice2 by dividing samples into a base dataset and a model-testing set. Model performance was assessed using receiver operating characteristic analysis and cross-validation (CV).

resultsOf the 87,092 SNPs initially considered, 24 were used to construct the PRS, located in intronic regions of genes such as

conclusionsThe developed PRS showed robust predictive ability for PCa in the Taiwanese population and may inform future risk stratification and personalized interventions.

Indexed as

Genetic risk scoreGenome-wide association studyPolymorphism, single nucleotideProstatic neoplasms

Identifiers

PMID40759595
PMCPMC13036242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.