Evidence map›Paper›PMID 40759592›Full record

ArticleThe world journal of men's health2026

Identification of a Novel Biallelic

Jun Ma, Tiechao Ruan, Chuan Jiang, Xiang Wang, Yingteng Zhang, Yunchuan Tian, Xinyao Tang, Yihong Yang, Ying Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun MaDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0002-2727-6421
Tiechao RuanDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-2924-0230
Chuan JiangDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-7049-4569
Xiang WangDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-8930-6801
Yingteng ZhangDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0003-7058-9797
Yunchuan TianDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0008-3431-1137
Xinyao TangDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0009-0008-6822-3725
Yihong YangReproduction Medical Center of West China Second University Hospital, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China. yyhpumc@foxmail.com.ORCID https://orcid.org/0000-0002-1206-2116
Ying ShenDepartment of Obstetrics and Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-6346-1002

Funding

National Natural Science Foundation of China 82471650Sichuan Science and Technology Program 2024YFFK0267
6 · The paper itself

Abstract

purposeInfertility affects approximately 10% to 20% of couples globally, with male factors contributing to nearly 50% of infertility cases. Among these, represents a severe form of male infertility, though its etiology remains largely unknown. CFAP119 has been implicated in sperm flagellar formation and is essential for fertility in mice; however, its role in human fertility has not been established. MATERIALS AND

methodsWhole exome sequencing (WES) was performed to identify pathogenic variants in a patient with asthenoteratozoospermia, and the functional impact of the mutations was assessed using

resultsIn this study, we identified a novel biallelic missense mutation in

conclusionsOur findings revealed novel pathogenic variants within

Indexed as

AsthenoteratozoospermiaCFAP119 protein, humanInfertility, maleSperm injections, intracytoplasmic

Identifiers

PMID40759592
PMCPMC12805148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.