Evidence map›Paper›PMID 40759286›Full record

ArticleNeurobiology of disease2025

Gasdermin D is activated but does not drive neurodegeneration in SOD1

Georgia Gunner, Himanish Basu, Yueting Lu, Matthew Bergstresser, Liwei Sun, Dylan Neel, So Yoen Choi, Isaac M Chiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers.Apoptosis : an international journal on programmed cell death · 2026
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Georgia GunnerHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
Himanish BasuHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
Yueting LuHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
Matthew BergstresserHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
Liwei SunHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
Dylan NeelHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
So Yoen ChoiHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA.
Isaac M ChiuHarvard Medical School, Department of Immunology, Blavatnik Institute Boston, MA 02115, USA. Electronic address: Isaac_chiu@hms.harvard.edu.

Funding

Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
Nociceptor neuron regulation of gastrointestinal barrier protection and host defenseR01DK127257 · NIDDK · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2021 to 2024
$2.2M
The role of gasdermins in microglial activation and neurodegeneration in ALS/FTDF32AG084174 · NIA · HARVARD MEDICAL SCHOOL · PI GUNNER, GEORGIA · 2023 to 2024
$143k
NIA NIH HHS F32 AG084174NIA NIH HHS T32 AG000222NIDDK NIH HHS R01 DK127257
6 · The paper itself

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, microgliosis, and neuroinflammation. While pyroptosis, an inflammatory form of programmed cell death, has been implicated in ALS, the specific role of Gasdermin D (GSDMD) - the primary executioner of pyroptosis - remains unexplored. In this study, we examined the function of GSDMD in the well-established SOD1

Indexed as

Amyotrophic Lateral SclerosisIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPyroptosisAnimalsDisease Models, AnimalFemaleGasderminsMaleMiceMice, Inbred C57BLMice, TransgenicMicrogliaMotor NeuronsNerve DegenerationSpinal CordGasderminsGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsSuperoxide Dismutase-1ALSCell deathGasdermin DMicrogliaNeuroimmunologyPyroptosis

Identifiers

PMID40759286
PMCPMC12412056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.