Evidence map›Paper›PMID 40759281›Full record

ArticleJournal of pediatric surgery2025

Impact of Early Plasma Resuscitation in Pediatric Severe Traumatic Brain Injury.

Leah Furman, Erin V Feeney, Barbara A Gaines, Christine M Leeper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leah FurmanDepartment of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Keystone Building, 3520 Fifth Avenue, Suite 500, Pittsburgh, PA, 15213, USA. Electronic address: furmanl@upmc.edu.
Erin V FeeneyDepartment of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Keystone Building, 3520 Fifth Avenue, Suite 500, Pittsburgh, PA, 15213, USA.
Barbara A GainesDepartment of Surgery, Division of Pediatric Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.
Christine M LeeperTrauma and Transfusion Medicine Research Center, University of Pittsburgh, Keystone Building, 3520 Fifth Avenue, Suite 500, Pittsburgh, PA, 15213, USA; Department of Surgery and Critical Care Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Funding

TRAINING IN TRAUMA AND SEPSIS RESEARCHT32GM008516 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 1994 to 2026
$9.4M
NIGMS NIH HHS T32 GM008516
6 · The paper itself

Abstract

backgroundTraumatic Brain Injury (TBI) is the leading cause of traumatic pediatric mortality. This study examined the safety of early plasma administration in children with severe TBI.

methodsA retrospective cohort study using data from a Level 1 pediatric trauma center from 2016 to 2023 was conducted. Children <18 years old with severe TBI (head Abbreviated Injury Scale (AIS) > 2 and requiring ICU admission) who received component plasma within 24 h of injury were included. Isolated asphyxiation and neck trauma were excluded. Subjects who received "early" plasma (≤4 h from injury) were propensity matched for age, sex, admission GCS, shock, ISS, maximum head AIS, and injury mechanism with those who received "delayed" plasma (>4-24 h post-injury). Adjusted logistic regression on the matched cohort assessed the association between plasma timing and 28-day mortality.

resultsOverall, 71 children met inclusion criteria; 31 received early and 40 received delayed plasma. The cohort was mostly male (66.2%) and injured via blunt mechanism (83.1%), with median(IQR) age 4(1-11) years, ISS 30(26-38), head AIS 5(4-5), and 28-day mortality rate of 62.0%. Among 31 propensity-matched pairs, there was no significant association between plasma timing and adjusted odds of 28-day mortality (Odds Ratio of early plasma 1.75 (95% CI: 0.42-7.31), p = 0.443), no transfusion reaction, and no increase in adverse events.

conclusionsIn this study of children with severe TBI, there were no apparent safety concerns with the receipt of early plasma compared to delayed plasma. Overall mortality was high, demonstrating need for additional therapies for this vulnerable population. TYPE OF STUDY: Retrospective cohort study. LEVEL OF EVIDENCE: Level III.

Indexed as

Blood Component TransfusionBrain Injuries, TraumaticPlasmaResuscitationAbbreviated Injury ScaleAdolescentChildChild, PreschoolFemaleHumansInfantMalePropensity ScoreRetrospective StudiesTime FactorsTrauma CentersPediatric brain injuryPediatric traumaPlasmaPlasma transfusionTraumatic brain injury

Identifiers

PMID40759281
PMCPMC12365635

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.